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Effects on prostate cancer cells of targeting RNA polymerase III

RNA polymerase (pol) III occurs in two forms, containing either the POLR3G subunit or the related paralogue POLR3GL. Whereas POLR3GL is ubiquitous, POLR3G is enriched in undifferentiated cells. Depletion of POLR3G selectively triggers proliferative arrest and differentiation of prostate cancer cells...

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Detalles Bibliográficos
Autores principales:	Petrie, John L, Swan, Caroline, Ingram, Richard M, Frame, Fiona M, Collins, Anne T, Dumay-Odelot, Hélène, Teichmann, Martin, Maitland, Norman J, White, Robert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486637/ https://www.ncbi.nlm.nih.gov/pubmed/30820548 http://dx.doi.org/10.1093/nar/gkz128

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