Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

There are adaptive T-cell and antibody autoimmune responses to myelin-derived peptides in multiple sclerosis (MS) and to aquaporin-4 (AQP4) in neuromyelitis optica spectrum disorders (NMOSDs). Strategies aimed at antigen-specific tolerance to these autoantigens are thus indicated for these diseases....

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Detalles Bibliográficos
Autores principales: Zubizarreta, Irati, Flórez-Grau, Georgina, Vila, Gemma, Cabezón, Raquel, España, Carolina, Andorra, Magi, Saiz, Albert, Llufriu, Sara, Sepulveda, Maria, Sola-Valls, Nuria, Martinez-Lapiscina, Elena H., Pulido-Valdeolivas, Irene, Casanova, Bonaventura, Martinez Gines, Marisa, Tellez, Nieves, Oreja-Guevara, Celia, Español, Marta, Trias, Esteve, Cid, Joan, Juan, Manel, Lozano, Miquel, Blanco, Yolanda, Steinman, Lawrence, Benitez-Ribas, Daniel, Villoslada, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486735/
https://www.ncbi.nlm.nih.gov/pubmed/30962374
http://dx.doi.org/10.1073/pnas.1820039116

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