CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function

Actin filaments (F-actin) are key components of sarcomeres, the basic contractile units of skeletal muscle myofibrils. A crucial step during myofibril differentiation is the sequential exchange of α-actin isoforms from smooth muscle (α-SMA) and cardiac (α-CAA) to skeletal muscle α-actin (α-SKA) that...

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Detalles Bibliográficos
Autores principales: Kepser, Lara-Jane, Damar, Fidan, De Cicco, Teresa, Chaponnier, Christine, Prószyński, Tomasz J., Pagenstecher, Axel, Rust, Marco B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486752/
https://www.ncbi.nlm.nih.gov/pubmed/30962377
http://dx.doi.org/10.1073/pnas.1813351116

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