Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging

PURPOSE: Several tracers have been designed for tracking the abnormal accumulation of tau pathology in vivo. Recently, concerns have been raised about the sources of off-target binding for these tracers; inconclusive data propose binding for some tracers to monoamine oxidase B (MAO-B). METHODS: Mole...

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Detalles Bibliográficos
Autores principales: Murugan, N. Arul, Chiotis, Konstantinos, Rodriguez-Vieitez, Elena, Lemoine, Laetitia, Ågren, Hans, Nordberg, Agneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486902/
https://www.ncbi.nlm.nih.gov/pubmed/30919054
http://dx.doi.org/10.1007/s00259-019-04305-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486902/
https://www.ncbi.nlm.nih.gov/pubmed/30919054
http://dx.doi.org/10.1007/s00259-019-04305-8

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