Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine

BACKGROUND: Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 methylation profiles in macroscopic normal intestin...

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Detalles Bibliográficos
Autores principales: Herberg, Maria, Siebert, Susann, Quaas, Marianne, Thalheim, Torsten, Rother, Karen, Hussong, Michelle, Altmüller, Janine, Kerner, Christiane, Galle, Joerg, Schweiger, Michal R., Aust, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486978/
https://www.ncbi.nlm.nih.gov/pubmed/31029155
http://dx.doi.org/10.1186/s13148-019-0639-8

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