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The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
BACKGROUND: Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial attention via event-related potential (ERP) examinations and explore further corre...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487030/ https://www.ncbi.nlm.nih.gov/pubmed/31029122 http://dx.doi.org/10.1186/s12883-019-1305-7 |
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author | Guo, Yunliang Tian, Qiang Xu, Song Han, Mimi Sun, Yue Hong, Yan Hou, Xunyao Liu, Xueping |
author_facet | Guo, Yunliang Tian, Qiang Xu, Song Han, Mimi Sun, Yue Hong, Yan Hou, Xunyao Liu, Xueping |
author_sort | Guo, Yunliang |
collection | PubMed |
description | BACKGROUND: Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial attention via event-related potential (ERP) examinations and explore further correlations between ERP data and migraine characteristics. METHODS: Altogether, 25 migraine patients (9 males, 16 females; mean age 35.240 years) in the interictal period and 21 age-matched healthy controls (8 males, 13 females; mean age 35.286 years) were recruited. A modified visual oddball paradigm which contained standard, target and novel stimuli was used in the test, and amplitudes and latencies of corresponding original/difference ERP components were measured and analyzed independently. RESULTS: We found that P3 amplitude was markedly reduced in migraineurs. This phenomenon was further validated in analysis of difference P3 components (target minus standard and novel minus standard). Additionally, the N1 and N2 latencies elicited by novel stimulus were both delayed in patients compared with controls. Furthermore, these deviant cognitive ERPs were correlated with frequency and duration of migraine attacks. CONCLUSIONS: These results indicated impaired visual spatial attention in migraine patients, which could be related to frequency and duration of attacks. |
format | Online Article Text |
id | pubmed-6487030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64870302019-05-06 The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm Guo, Yunliang Tian, Qiang Xu, Song Han, Mimi Sun, Yue Hong, Yan Hou, Xunyao Liu, Xueping BMC Neurol Research Article BACKGROUND: Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial attention via event-related potential (ERP) examinations and explore further correlations between ERP data and migraine characteristics. METHODS: Altogether, 25 migraine patients (9 males, 16 females; mean age 35.240 years) in the interictal period and 21 age-matched healthy controls (8 males, 13 females; mean age 35.286 years) were recruited. A modified visual oddball paradigm which contained standard, target and novel stimuli was used in the test, and amplitudes and latencies of corresponding original/difference ERP components were measured and analyzed independently. RESULTS: We found that P3 amplitude was markedly reduced in migraineurs. This phenomenon was further validated in analysis of difference P3 components (target minus standard and novel minus standard). Additionally, the N1 and N2 latencies elicited by novel stimulus were both delayed in patients compared with controls. Furthermore, these deviant cognitive ERPs were correlated with frequency and duration of migraine attacks. CONCLUSIONS: These results indicated impaired visual spatial attention in migraine patients, which could be related to frequency and duration of attacks. BioMed Central 2019-04-27 /pmc/articles/PMC6487030/ /pubmed/31029122 http://dx.doi.org/10.1186/s12883-019-1305-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Guo, Yunliang Tian, Qiang Xu, Song Han, Mimi Sun, Yue Hong, Yan Hou, Xunyao Liu, Xueping The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
title | The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
title_full | The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
title_fullStr | The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
title_full_unstemmed | The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
title_short | The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
title_sort | impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487030/ https://www.ncbi.nlm.nih.gov/pubmed/31029122 http://dx.doi.org/10.1186/s12883-019-1305-7 |
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