Cargando…

The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm

BACKGROUND: Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial attention via event-related potential (ERP) examinations and explore further corre...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yunliang, Tian, Qiang, Xu, Song, Han, Mimi, Sun, Yue, Hong, Yan, Hou, Xunyao, Liu, Xueping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487030/
https://www.ncbi.nlm.nih.gov/pubmed/31029122
http://dx.doi.org/10.1186/s12883-019-1305-7
_version_ 1783414425313607680
author Guo, Yunliang
Tian, Qiang
Xu, Song
Han, Mimi
Sun, Yue
Hong, Yan
Hou, Xunyao
Liu, Xueping
author_facet Guo, Yunliang
Tian, Qiang
Xu, Song
Han, Mimi
Sun, Yue
Hong, Yan
Hou, Xunyao
Liu, Xueping
author_sort Guo, Yunliang
collection PubMed
description BACKGROUND: Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial attention via event-related potential (ERP) examinations and explore further correlations between ERP data and migraine characteristics. METHODS: Altogether, 25 migraine patients (9 males, 16 females; mean age 35.240 years) in the interictal period and 21 age-matched healthy controls (8 males, 13 females; mean age 35.286 years) were recruited. A modified visual oddball paradigm which contained standard, target and novel stimuli was used in the test, and amplitudes and latencies of corresponding original/difference ERP components were measured and analyzed independently. RESULTS: We found that P3 amplitude was markedly reduced in migraineurs. This phenomenon was further validated in analysis of difference P3 components (target minus standard and novel minus standard). Additionally, the N1 and N2 latencies elicited by novel stimulus were both delayed in patients compared with controls. Furthermore, these deviant cognitive ERPs were correlated with frequency and duration of migraine attacks. CONCLUSIONS: These results indicated impaired visual spatial attention in migraine patients, which could be related to frequency and duration of attacks.
format Online
Article
Text
id pubmed-6487030
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-64870302019-05-06 The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm Guo, Yunliang Tian, Qiang Xu, Song Han, Mimi Sun, Yue Hong, Yan Hou, Xunyao Liu, Xueping BMC Neurol Research Article BACKGROUND: Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial attention via event-related potential (ERP) examinations and explore further correlations between ERP data and migraine characteristics. METHODS: Altogether, 25 migraine patients (9 males, 16 females; mean age 35.240 years) in the interictal period and 21 age-matched healthy controls (8 males, 13 females; mean age 35.286 years) were recruited. A modified visual oddball paradigm which contained standard, target and novel stimuli was used in the test, and amplitudes and latencies of corresponding original/difference ERP components were measured and analyzed independently. RESULTS: We found that P3 amplitude was markedly reduced in migraineurs. This phenomenon was further validated in analysis of difference P3 components (target minus standard and novel minus standard). Additionally, the N1 and N2 latencies elicited by novel stimulus were both delayed in patients compared with controls. Furthermore, these deviant cognitive ERPs were correlated with frequency and duration of migraine attacks. CONCLUSIONS: These results indicated impaired visual spatial attention in migraine patients, which could be related to frequency and duration of attacks. BioMed Central 2019-04-27 /pmc/articles/PMC6487030/ /pubmed/31029122 http://dx.doi.org/10.1186/s12883-019-1305-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Guo, Yunliang
Tian, Qiang
Xu, Song
Han, Mimi
Sun, Yue
Hong, Yan
Hou, Xunyao
Liu, Xueping
The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
title The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
title_full The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
title_fullStr The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
title_full_unstemmed The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
title_short The impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
title_sort impact of attack frequency and duration on neurocognitive processing in migraine sufferers: evidence from event-related potentials using a modified oddball paradigm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487030/
https://www.ncbi.nlm.nih.gov/pubmed/31029122
http://dx.doi.org/10.1186/s12883-019-1305-7
work_keys_str_mv AT guoyunliang theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT tianqiang theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT xusong theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT hanmimi theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT sunyue theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT hongyan theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT houxunyao theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT liuxueping theimpactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT guoyunliang impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT tianqiang impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT xusong impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT hanmimi impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT sunyue impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT hongyan impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT houxunyao impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm
AT liuxueping impactofattackfrequencyanddurationonneurocognitiveprocessinginmigrainesufferersevidencefromeventrelatedpotentialsusingamodifiedoddballparadigm