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The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia

INTRODUCTION: Opuntia ficus indica L. inermis (OFI) is used in traditional medicine pharmacopeia for its richness in natural bioactive compounds. It has been proven to be effective in the improvement of the healing of laser-induced skin burns. The aim of the present study was to investigate the woun...

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Autores principales: Khémiri, Ikram, Essghaier Hédi, Badiaa, Sadfi Zouaoui, Najla, Ben Gdara, Neyla, Bitri, Lotfi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487086/
https://www.ncbi.nlm.nih.gov/pubmed/31097975
http://dx.doi.org/10.1155/2019/9148782
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author Khémiri, Ikram
Essghaier Hédi, Badiaa
Sadfi Zouaoui, Najla
Ben Gdara, Neyla
Bitri, Lotfi
author_facet Khémiri, Ikram
Essghaier Hédi, Badiaa
Sadfi Zouaoui, Najla
Ben Gdara, Neyla
Bitri, Lotfi
author_sort Khémiri, Ikram
collection PubMed
description INTRODUCTION: Opuntia ficus indica L. inermis (OFI) is used in traditional medicine pharmacopeia for its richness in natural bioactive compounds. It has been proven to be effective in the improvement of the healing of laser-induced skin burns. The aim of the present study was to investigate the wound healing effect of OFI extracted oil on full-thickness skin wound. MATERIALS AND METHODS: The OFI seeds were firstly isolated from mature prickly pears, washed, dried, and then cold-pressed. The antimicrobial activities of OFI seed oil were estimated in vitro against bacteria, yeast, and fungi. Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were calculated. Skin wound healing was investigated using an excisional wound healing model in rats. The skin wounds of three experimental groups of rats were topically treated once/day with saline solution (control group), 0.15 mg/mm(2) of a reference drug Esth'Elle Pharma Cicaplaie cream (reference group), and 0.6 μl/mm(2) of OFI seed oil (OFI oil group). The healing process was monitored daily and the percentage of wound contraction was calculated. A histological study was carried on skin biopsies. RESULTS: The extracted oil has shown an interesting antimicrobial effect on Enterobacter cloacae, antiyeast effect against Candida parapsilosis and Candida sake, and antifungal activity against three opportunistic cutaneous molds (Penicillium, Aspergillus, and Fusarium). Moreover, OFI oil has shown a good wound healing effect. It prevents cutaneous infections and reduces the reepithelialization phase. CONCLUSION: OFI extracted oil has in vitro antimicrobial/fungal properties and in vivo wound healing activity. It seems to be efficient in the treatment of cutaneous infections and the promoting of the scarring process.
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spelling pubmed-64870862019-05-16 The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia Khémiri, Ikram Essghaier Hédi, Badiaa Sadfi Zouaoui, Najla Ben Gdara, Neyla Bitri, Lotfi Evid Based Complement Alternat Med Research Article INTRODUCTION: Opuntia ficus indica L. inermis (OFI) is used in traditional medicine pharmacopeia for its richness in natural bioactive compounds. It has been proven to be effective in the improvement of the healing of laser-induced skin burns. The aim of the present study was to investigate the wound healing effect of OFI extracted oil on full-thickness skin wound. MATERIALS AND METHODS: The OFI seeds were firstly isolated from mature prickly pears, washed, dried, and then cold-pressed. The antimicrobial activities of OFI seed oil were estimated in vitro against bacteria, yeast, and fungi. Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were calculated. Skin wound healing was investigated using an excisional wound healing model in rats. The skin wounds of three experimental groups of rats were topically treated once/day with saline solution (control group), 0.15 mg/mm(2) of a reference drug Esth'Elle Pharma Cicaplaie cream (reference group), and 0.6 μl/mm(2) of OFI seed oil (OFI oil group). The healing process was monitored daily and the percentage of wound contraction was calculated. A histological study was carried on skin biopsies. RESULTS: The extracted oil has shown an interesting antimicrobial effect on Enterobacter cloacae, antiyeast effect against Candida parapsilosis and Candida sake, and antifungal activity against three opportunistic cutaneous molds (Penicillium, Aspergillus, and Fusarium). Moreover, OFI oil has shown a good wound healing effect. It prevents cutaneous infections and reduces the reepithelialization phase. CONCLUSION: OFI extracted oil has in vitro antimicrobial/fungal properties and in vivo wound healing activity. It seems to be efficient in the treatment of cutaneous infections and the promoting of the scarring process. Hindawi 2019-04-14 /pmc/articles/PMC6487086/ /pubmed/31097975 http://dx.doi.org/10.1155/2019/9148782 Text en Copyright © 2019 Ikram Khémiri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khémiri, Ikram
Essghaier Hédi, Badiaa
Sadfi Zouaoui, Najla
Ben Gdara, Neyla
Bitri, Lotfi
The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia
title The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia
title_full The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia
title_fullStr The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia
title_full_unstemmed The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia
title_short The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia
title_sort antimicrobial and wound healing potential of opuntia ficus indica l. inermis extracted oil from tunisia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487086/
https://www.ncbi.nlm.nih.gov/pubmed/31097975
http://dx.doi.org/10.1155/2019/9148782
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