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Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs
Adult neurogenesis in the hippocampal dentate gyrus (DG) modulates cognition and behavior in mammals, while motherhood is associated with cognitive and behavioral changes essential for the care of the young. In mice and rats, hippocampal neurogenesis is reported to be reduced or unchanged during pre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487096/ https://www.ncbi.nlm.nih.gov/pubmed/31097956 http://dx.doi.org/10.1155/2019/5765284 |
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author | Wan, Lily Tu, Tian Zhang, Qi-Lei Jiang, Juan Yan, Xiao-Xin |
author_facet | Wan, Lily Tu, Tian Zhang, Qi-Lei Jiang, Juan Yan, Xiao-Xin |
author_sort | Wan, Lily |
collection | PubMed |
description | Adult neurogenesis in the hippocampal dentate gyrus (DG) modulates cognition and behavior in mammals, while motherhood is associated with cognitive and behavioral changes essential for the care of the young. In mice and rats, hippocampal neurogenesis is reported to be reduced or unchanged during pregnancy, with few data available from other species. In guinea pigs, pregnancy lasts ~9 weeks; we set to explore if hippocampal neurogenesis is altered in these animals, relative to gestational stages. Time-pregnant primigravidas (3-5 months old) and age-matched nonpregnant females were examined, with neurogenic potential evaluated via immunolabeling of Ki67, Sp8, doublecortin (DCX), and neuron-specific nuclear antigen (NeuN) combined with bromodeoxyuridine (BrdU) birth-dating. Relative to control, subgranular Ki67, Sp8, and DCX-immunoreactive (+) cells tended to increase from early gestation to postpartum and peaked at the late gestational stage. In BrdU pulse-chasing experiments in nonpregnant females surviving for different time points (2-120 days), BrdU+ cells in the DG colocalized with DCX partially from 2 to 42 days (most frequently at 14-30 days) and with NeuN increasingly from 14 to 120 days. In pregnant females that received BrdU at early, middle, and late gestational stages and survived for 42 days, the density of BrdU+ cells in the DG was mostly high in the late gestational group. The rates of BrdU/DCX and BrdU/NeuN colocalization were similar among these groups and comparable to those among the corresponding control group. Together, the findings suggest that pregnancy promotes maternal hippocampal neurogenesis in guinea pigs, at least among primigravidas. |
format | Online Article Text |
id | pubmed-6487096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64870962019-05-16 Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs Wan, Lily Tu, Tian Zhang, Qi-Lei Jiang, Juan Yan, Xiao-Xin Neural Plast Research Article Adult neurogenesis in the hippocampal dentate gyrus (DG) modulates cognition and behavior in mammals, while motherhood is associated with cognitive and behavioral changes essential for the care of the young. In mice and rats, hippocampal neurogenesis is reported to be reduced or unchanged during pregnancy, with few data available from other species. In guinea pigs, pregnancy lasts ~9 weeks; we set to explore if hippocampal neurogenesis is altered in these animals, relative to gestational stages. Time-pregnant primigravidas (3-5 months old) and age-matched nonpregnant females were examined, with neurogenic potential evaluated via immunolabeling of Ki67, Sp8, doublecortin (DCX), and neuron-specific nuclear antigen (NeuN) combined with bromodeoxyuridine (BrdU) birth-dating. Relative to control, subgranular Ki67, Sp8, and DCX-immunoreactive (+) cells tended to increase from early gestation to postpartum and peaked at the late gestational stage. In BrdU pulse-chasing experiments in nonpregnant females surviving for different time points (2-120 days), BrdU+ cells in the DG colocalized with DCX partially from 2 to 42 days (most frequently at 14-30 days) and with NeuN increasingly from 14 to 120 days. In pregnant females that received BrdU at early, middle, and late gestational stages and survived for 42 days, the density of BrdU+ cells in the DG was mostly high in the late gestational group. The rates of BrdU/DCX and BrdU/NeuN colocalization were similar among these groups and comparable to those among the corresponding control group. Together, the findings suggest that pregnancy promotes maternal hippocampal neurogenesis in guinea pigs, at least among primigravidas. Hindawi 2019-04-11 /pmc/articles/PMC6487096/ /pubmed/31097956 http://dx.doi.org/10.1155/2019/5765284 Text en Copyright © 2019 Lily Wan et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wan, Lily Tu, Tian Zhang, Qi-Lei Jiang, Juan Yan, Xiao-Xin Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs |
title | Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs |
title_full | Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs |
title_fullStr | Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs |
title_full_unstemmed | Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs |
title_short | Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs |
title_sort | pregnancy promotes maternal hippocampal neurogenesis in guinea pigs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487096/ https://www.ncbi.nlm.nih.gov/pubmed/31097956 http://dx.doi.org/10.1155/2019/5765284 |
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