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Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women

Soy isoflavones have several potential benefits related to postmenopausal health. Isoflavone glycosides, found predominantly in nonfermented soy products, e.g., soy milk, require conversion by gut microbiota to their respective bioavailable aglycones prior to absorption into portal circulation. Use...

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Autores principales: Temyingyong, Nathathai, Koonrungsesomboon, Nut, Hanprasertpong, Nutthiya, Na Takuathung, Mingkwan, Teekachunhatean, Supanimit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487098/
https://www.ncbi.nlm.nih.gov/pubmed/31097972
http://dx.doi.org/10.1155/2019/7192326
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author Temyingyong, Nathathai
Koonrungsesomboon, Nut
Hanprasertpong, Nutthiya
Na Takuathung, Mingkwan
Teekachunhatean, Supanimit
author_facet Temyingyong, Nathathai
Koonrungsesomboon, Nut
Hanprasertpong, Nutthiya
Na Takuathung, Mingkwan
Teekachunhatean, Supanimit
author_sort Temyingyong, Nathathai
collection PubMed
description Soy isoflavones have several potential benefits related to postmenopausal health. Isoflavone glycosides, found predominantly in nonfermented soy products, e.g., soy milk, require conversion by gut microbiota to their respective bioavailable aglycones prior to absorption into portal circulation. Use of short-course oral ciprofloxacin for the treatment of acute uncomplicated cystitis, the incidence of which is increasing among postmenopausal women, might adversely affect gut microbiota. The objective of this one-group pre-post treatment study was to determine the effect of short-course oral ciprofloxacin on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven postmenopausal subjects were assigned to consume a single oral dose of 375 mL UHT soy milk (SOY phase). Blood samples were collected immediately before soy milk ingestion and at specific times for 32 hours after soy milk ingestion. Following a washout period of at least seven days, subjects were assigned to take 250 mg oral ciprofloxacin after breakfast and dinner for three days, followed by a single oral dose of 375 mL UHT soy milk the next day (CIPRO/SOY phase). Blood samples were collected at the same time points as in the SOY phase. Plasma samples were treated with β-glucuronidase/sulfatase and plasma concentrations of aglycones (genistein and daidzein) were determined using high-performance liquid chromatography. C(max), AUC(0-t), and AUC(0-∞) of both aglycones and T(max) of genistein obtained from the CIPRO/SOY phase were significantly lower than those obtained from the SOY phase, while T(max) of daidzein and t(1/2) of both aglycones in the two phases were not significantly different.
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spelling pubmed-64870982019-05-16 Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women Temyingyong, Nathathai Koonrungsesomboon, Nut Hanprasertpong, Nutthiya Na Takuathung, Mingkwan Teekachunhatean, Supanimit Evid Based Complement Alternat Med Research Article Soy isoflavones have several potential benefits related to postmenopausal health. Isoflavone glycosides, found predominantly in nonfermented soy products, e.g., soy milk, require conversion by gut microbiota to their respective bioavailable aglycones prior to absorption into portal circulation. Use of short-course oral ciprofloxacin for the treatment of acute uncomplicated cystitis, the incidence of which is increasing among postmenopausal women, might adversely affect gut microbiota. The objective of this one-group pre-post treatment study was to determine the effect of short-course oral ciprofloxacin on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven postmenopausal subjects were assigned to consume a single oral dose of 375 mL UHT soy milk (SOY phase). Blood samples were collected immediately before soy milk ingestion and at specific times for 32 hours after soy milk ingestion. Following a washout period of at least seven days, subjects were assigned to take 250 mg oral ciprofloxacin after breakfast and dinner for three days, followed by a single oral dose of 375 mL UHT soy milk the next day (CIPRO/SOY phase). Blood samples were collected at the same time points as in the SOY phase. Plasma samples were treated with β-glucuronidase/sulfatase and plasma concentrations of aglycones (genistein and daidzein) were determined using high-performance liquid chromatography. C(max), AUC(0-t), and AUC(0-∞) of both aglycones and T(max) of genistein obtained from the CIPRO/SOY phase were significantly lower than those obtained from the SOY phase, while T(max) of daidzein and t(1/2) of both aglycones in the two phases were not significantly different. Hindawi 2019-04-11 /pmc/articles/PMC6487098/ /pubmed/31097972 http://dx.doi.org/10.1155/2019/7192326 Text en Copyright © 2019 Nathathai Temyingyong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Temyingyong, Nathathai
Koonrungsesomboon, Nut
Hanprasertpong, Nutthiya
Na Takuathung, Mingkwan
Teekachunhatean, Supanimit
Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women
title Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women
title_full Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women
title_fullStr Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women
title_full_unstemmed Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women
title_short Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women
title_sort effect of short-course oral ciprofloxacin on isoflavone pharmacokinetics following soy milk ingestion in healthy postmenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487098/
https://www.ncbi.nlm.nih.gov/pubmed/31097972
http://dx.doi.org/10.1155/2019/7192326
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