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Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population

Gestational diabetes mellitus (GDM) is a growing public health concern for many reasons, and its etiology remains unclear. Due to the similarity of its pathophysiology with type 2 diabetes (T2DM), we evaluated the relationship between published T2DM susceptibility genes and the risk of GDM. A total...

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Autores principales: Wang, Keke, Chen, Qiong, Feng, Yongliang, Yang, Hailan, Wu, Weiwei, Zhang, Ping, Wang, Ying, Ko, Jamie, Zhao, Feng, Du, Wenqiong, Yang, Feifei, Han, Tianbi, Wang, Suping, Zhang, Yawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487100/
https://www.ncbi.nlm.nih.gov/pubmed/31098383
http://dx.doi.org/10.1155/2019/3618103
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author Wang, Keke
Chen, Qiong
Feng, Yongliang
Yang, Hailan
Wu, Weiwei
Zhang, Ping
Wang, Ying
Ko, Jamie
Zhao, Feng
Du, Wenqiong
Yang, Feifei
Han, Tianbi
Wang, Suping
Zhang, Yawei
author_facet Wang, Keke
Chen, Qiong
Feng, Yongliang
Yang, Hailan
Wu, Weiwei
Zhang, Ping
Wang, Ying
Ko, Jamie
Zhao, Feng
Du, Wenqiong
Yang, Feifei
Han, Tianbi
Wang, Suping
Zhang, Yawei
author_sort Wang, Keke
collection PubMed
description Gestational diabetes mellitus (GDM) is a growing public health concern for many reasons, and its etiology remains unclear. Due to the similarity of its pathophysiology with type 2 diabetes (T2DM), we evaluated the relationship between published T2DM susceptibility genes and the risk of GDM. A total of 303 SNPs from genes including IRS1, IGF2BP2, CDKAL1, GCK, TCF7L2, KCNQ1, and KCNJ11 and the risk of GDM were examined in a nested case-control study with 321 GDM cases and 316 controls. The odds ratios (ORs) and their 95% confidence interval (95% CI) were estimated by unconditional logistical regression as a measure of the associations between genotypes and GDM in additive, recessive, dominant, and codominant models adjusting for maternal age, maternal BMI, parity, and family history of diabetes. At the gene level, CDKAL1 was associated with GDM risk. SNPs in the CDKAL1 gene including rs4712527, rs7748720, rs9350276, and rs6938256 were associated with reduced GDM risk. However, SNPs including rs9295478, rs6935599, and rs7747752 were associated with elevated GDM risk. After adjusting for multiple comparisons, rs9295478 and rs6935599 were still significant across the additive, recessive, and codominant models; rs7748720 and rs6938256 were significant in dominant and codominant models; and rs4712527 was only significant in the codominant model. Our study provides evidence for an association between the CDKAL1 gene and risk of GDM. However, its role in the GDM pathogenesis still needs to be verified by further studies.
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spelling pubmed-64871002019-05-16 Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population Wang, Keke Chen, Qiong Feng, Yongliang Yang, Hailan Wu, Weiwei Zhang, Ping Wang, Ying Ko, Jamie Zhao, Feng Du, Wenqiong Yang, Feifei Han, Tianbi Wang, Suping Zhang, Yawei J Diabetes Res Research Article Gestational diabetes mellitus (GDM) is a growing public health concern for many reasons, and its etiology remains unclear. Due to the similarity of its pathophysiology with type 2 diabetes (T2DM), we evaluated the relationship between published T2DM susceptibility genes and the risk of GDM. A total of 303 SNPs from genes including IRS1, IGF2BP2, CDKAL1, GCK, TCF7L2, KCNQ1, and KCNJ11 and the risk of GDM were examined in a nested case-control study with 321 GDM cases and 316 controls. The odds ratios (ORs) and their 95% confidence interval (95% CI) were estimated by unconditional logistical regression as a measure of the associations between genotypes and GDM in additive, recessive, dominant, and codominant models adjusting for maternal age, maternal BMI, parity, and family history of diabetes. At the gene level, CDKAL1 was associated with GDM risk. SNPs in the CDKAL1 gene including rs4712527, rs7748720, rs9350276, and rs6938256 were associated with reduced GDM risk. However, SNPs including rs9295478, rs6935599, and rs7747752 were associated with elevated GDM risk. After adjusting for multiple comparisons, rs9295478 and rs6935599 were still significant across the additive, recessive, and codominant models; rs7748720 and rs6938256 were significant in dominant and codominant models; and rs4712527 was only significant in the codominant model. Our study provides evidence for an association between the CDKAL1 gene and risk of GDM. However, its role in the GDM pathogenesis still needs to be verified by further studies. Hindawi 2019-04-14 /pmc/articles/PMC6487100/ /pubmed/31098383 http://dx.doi.org/10.1155/2019/3618103 Text en Copyright © 2019 Keke Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Keke
Chen, Qiong
Feng, Yongliang
Yang, Hailan
Wu, Weiwei
Zhang, Ping
Wang, Ying
Ko, Jamie
Zhao, Feng
Du, Wenqiong
Yang, Feifei
Han, Tianbi
Wang, Suping
Zhang, Yawei
Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population
title Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population
title_full Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population
title_fullStr Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population
title_full_unstemmed Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population
title_short Single Nucleotide Polymorphisms in CDKAL1 Gene Are Associated with Risk of Gestational Diabetes Mellitus in Chinese Population
title_sort single nucleotide polymorphisms in cdkal1 gene are associated with risk of gestational diabetes mellitus in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487100/
https://www.ncbi.nlm.nih.gov/pubmed/31098383
http://dx.doi.org/10.1155/2019/3618103
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