Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagn...

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Autores principales: Mariotti, Benedetta, Meconi, Federico, Palmieri, Raffaele, De Bellis, Eleonora, Lavorgna, Serena, Ottone, Tiziana, Martini, Vincenza, Lo-Coco, Francesco, Cicconi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487162/
https://www.ncbi.nlm.nih.gov/pubmed/31110828
http://dx.doi.org/10.1155/2019/6707506
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author Mariotti, Benedetta
Meconi, Federico
Palmieri, Raffaele
De Bellis, Eleonora
Lavorgna, Serena
Ottone, Tiziana
Martini, Vincenza
Lo-Coco, Francesco
Cicconi, Laura
author_facet Mariotti, Benedetta
Meconi, Federico
Palmieri, Raffaele
De Bellis, Eleonora
Lavorgna, Serena
Ottone, Tiziana
Martini, Vincenza
Lo-Coco, Francesco
Cicconi, Laura
author_sort Mariotti, Benedetta
collection PubMed
description We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.
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spelling pubmed-64871622019-05-20 Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations Mariotti, Benedetta Meconi, Federico Palmieri, Raffaele De Bellis, Eleonora Lavorgna, Serena Ottone, Tiziana Martini, Vincenza Lo-Coco, Francesco Cicconi, Laura Case Rep Hematol Case Report We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options. Hindawi 2019-04-11 /pmc/articles/PMC6487162/ /pubmed/31110828 http://dx.doi.org/10.1155/2019/6707506 Text en Copyright © 2019 Benedetta Mariotti et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mariotti, Benedetta
Meconi, Federico
Palmieri, Raffaele
De Bellis, Eleonora
Lavorgna, Serena
Ottone, Tiziana
Martini, Vincenza
Lo-Coco, Francesco
Cicconi, Laura
Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
title Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
title_full Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
title_fullStr Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
title_full_unstemmed Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
title_short Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
title_sort acute myeloid leukemia with concomitant bcr-abl and npm1 mutations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487162/
https://www.ncbi.nlm.nih.gov/pubmed/31110828
http://dx.doi.org/10.1155/2019/6707506
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