The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review

Chondrocytes are the sole cellular constituents of normal cartilage. The degeneration and apoptosis of these cells are considered the main cause of osteoarthritis (OA). Previous studies have suggested that the enhancement of autophagy in chondrocytes can delay the progression of osteoarthritis by af...

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Detalles Bibliográficos
Autores principales: Luo, Pan, Gao, Fuqiang, Niu, Dongsheng, Sun, Xichun, Song, Qiang, Guo, Chongjun, Liang, Yuqi, Sun, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487163/
https://www.ncbi.nlm.nih.gov/pubmed/31111057
http://dx.doi.org/10.1155/2019/5171602
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author Luo, Pan
Gao, Fuqiang
Niu, Dongsheng
Sun, Xichun
Song, Qiang
Guo, Chongjun
Liang, Yuqi
Sun, Wei
author_facet Luo, Pan
Gao, Fuqiang
Niu, Dongsheng
Sun, Xichun
Song, Qiang
Guo, Chongjun
Liang, Yuqi
Sun, Wei
author_sort Luo, Pan
collection PubMed
description Chondrocytes are the sole cellular constituents of normal cartilage. The degeneration and apoptosis of these cells are considered the main cause of osteoarthritis (OA). Previous studies have suggested that the enhancement of autophagy in chondrocytes can delay the progression of osteoarthritis by affecting intracellular metabolic activity, i.e., by regulating the metabolism of nutrients, which can delay cell aging and death. In this review, we explored the relationship between autophagy and chondrocyte metabolism and provided new ideas for the prevention and treatment of OA.
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spelling pubmed-64871632019-05-20 The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review Luo, Pan Gao, Fuqiang Niu, Dongsheng Sun, Xichun Song, Qiang Guo, Chongjun Liang, Yuqi Sun, Wei Biomed Res Int Review Article Chondrocytes are the sole cellular constituents of normal cartilage. The degeneration and apoptosis of these cells are considered the main cause of osteoarthritis (OA). Previous studies have suggested that the enhancement of autophagy in chondrocytes can delay the progression of osteoarthritis by affecting intracellular metabolic activity, i.e., by regulating the metabolism of nutrients, which can delay cell aging and death. In this review, we explored the relationship between autophagy and chondrocyte metabolism and provided new ideas for the prevention and treatment of OA. Hindawi 2019-04-14 /pmc/articles/PMC6487163/ /pubmed/31111057 http://dx.doi.org/10.1155/2019/5171602 Text en Copyright © 2019 Pan Luo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Luo, Pan
Gao, Fuqiang
Niu, Dongsheng
Sun, Xichun
Song, Qiang
Guo, Chongjun
Liang, Yuqi
Sun, Wei
The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review
title The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review
title_full The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review
title_fullStr The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review
title_full_unstemmed The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review
title_short The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review
title_sort role of autophagy in chondrocyte metabolism and osteoarthritis: a comprehensive research review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487163/
https://www.ncbi.nlm.nih.gov/pubmed/31111057
http://dx.doi.org/10.1155/2019/5171602
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