An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient

We herein describe the first case of thrombotic microangiopathy (TMA) which was related to Shiga toxin producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) after lung transplantation. His maintenance immunosuppression relied on tacrolimus plus mycophenolic acid. TMA was treated with p...

Descripción completa

Detalles Bibliográficos
Autores principales: Manière, Louis, Domenger, Camille, Camara, Boubou, Giovannini, Diane, Malvezzi, Paolo, Rostaing, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487164/
https://www.ncbi.nlm.nih.gov/pubmed/31110835
http://dx.doi.org/10.1155/2019/9465040
_version_ 1783414456098750464
author Manière, Louis
Domenger, Camille
Camara, Boubou
Giovannini, Diane
Malvezzi, Paolo
Rostaing, Lionel
author_facet Manière, Louis
Domenger, Camille
Camara, Boubou
Giovannini, Diane
Malvezzi, Paolo
Rostaing, Lionel
author_sort Manière, Louis
collection PubMed
description We herein describe the first case of thrombotic microangiopathy (TMA) which was related to Shiga toxin producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) after lung transplantation. His maintenance immunosuppression relied on tacrolimus plus mycophenolic acid. TMA was treated with plasma exchanges (PE) (fresh frozen plasma substitution). After five days of PE, platelets count and lactate dehydrogenase level normalized, whereas hemoglobin continued to gradually decrease and no improvement in kidney function was observed. After seven PE sessions, all TMA biological signs resolved. However, kidney function did not improve, and the patient still required chronic dialysis.
format Online
Article
Text
id pubmed-6487164
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-64871642019-05-20 An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient Manière, Louis Domenger, Camille Camara, Boubou Giovannini, Diane Malvezzi, Paolo Rostaing, Lionel Case Rep Transplant Case Report We herein describe the first case of thrombotic microangiopathy (TMA) which was related to Shiga toxin producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) after lung transplantation. His maintenance immunosuppression relied on tacrolimus plus mycophenolic acid. TMA was treated with plasma exchanges (PE) (fresh frozen plasma substitution). After five days of PE, platelets count and lactate dehydrogenase level normalized, whereas hemoglobin continued to gradually decrease and no improvement in kidney function was observed. After seven PE sessions, all TMA biological signs resolved. However, kidney function did not improve, and the patient still required chronic dialysis. Hindawi 2019-04-11 /pmc/articles/PMC6487164/ /pubmed/31110835 http://dx.doi.org/10.1155/2019/9465040 Text en Copyright © 2019 Louis Manière et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Manière, Louis
Domenger, Camille
Camara, Boubou
Giovannini, Diane
Malvezzi, Paolo
Rostaing, Lionel
An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
title An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
title_full An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
title_fullStr An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
title_full_unstemmed An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
title_short An Atypical Case of Shiga Toxin Producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
title_sort atypical case of shiga toxin producing-escherichia coli hemolytic and uremic syndrome (stec-hus) in a lung transplant recipient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487164/
https://www.ncbi.nlm.nih.gov/pubmed/31110835
http://dx.doi.org/10.1155/2019/9465040
work_keys_str_mv AT manierelouis anatypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT domengercamille anatypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT camaraboubou anatypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT giovanninidiane anatypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT malvezzipaolo anatypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT rostainglionel anatypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT manierelouis atypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT domengercamille atypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT camaraboubou atypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT giovanninidiane atypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT malvezzipaolo atypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient
AT rostainglionel atypicalcaseofshigatoxinproducingescherichiacolihemolyticanduremicsyndromestechusinalungtransplantrecipient

Ejemplares similares