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Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess

Large pyogenic liver abscess is a rare and difficult to treat entity in pediatric patients. Percutaneous drainage rather than open surgical drainage has become more common in recent years, even for large abscesses. Percutaneous drainage can be complicated by catheter obstruction. We present the case...

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Autores principales: Zee-Cheng, Janine, Fox, Thomas, Patel, Sonal, Abu-Sultaneh, Samer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487166/
https://www.ncbi.nlm.nih.gov/pubmed/31161070
http://dx.doi.org/10.1155/2019/5735312
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author Zee-Cheng, Janine
Fox, Thomas
Patel, Sonal
Abu-Sultaneh, Samer
author_facet Zee-Cheng, Janine
Fox, Thomas
Patel, Sonal
Abu-Sultaneh, Samer
author_sort Zee-Cheng, Janine
collection PubMed
description Large pyogenic liver abscess is a rare and difficult to treat entity in pediatric patients. Percutaneous drainage rather than open surgical drainage has become more common in recent years, even for large abscesses. Percutaneous drainage can be complicated by catheter obstruction. We present the case of a 16-year-old male presenting with abdominal pain, fever, and chills. He was diagnosed with a 9-centimeter liver abscess. A CT-guided percutaneous drainage was placed. The catheter initially drained well, but then became occluded. Tissue plasminogen activator was instilled into the catheter every 6 hours for a total of five doses, resulting in increased drainage and improved clinical state of the patient. To our knowledge, this is the first reported use of tissue plasminogen activator in pyogenic liver abscess in the pediatric population.
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spelling pubmed-64871662019-06-03 Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess Zee-Cheng, Janine Fox, Thomas Patel, Sonal Abu-Sultaneh, Samer Case Rep Crit Care Case Report Large pyogenic liver abscess is a rare and difficult to treat entity in pediatric patients. Percutaneous drainage rather than open surgical drainage has become more common in recent years, even for large abscesses. Percutaneous drainage can be complicated by catheter obstruction. We present the case of a 16-year-old male presenting with abdominal pain, fever, and chills. He was diagnosed with a 9-centimeter liver abscess. A CT-guided percutaneous drainage was placed. The catheter initially drained well, but then became occluded. Tissue plasminogen activator was instilled into the catheter every 6 hours for a total of five doses, resulting in increased drainage and improved clinical state of the patient. To our knowledge, this is the first reported use of tissue plasminogen activator in pyogenic liver abscess in the pediatric population. Hindawi 2019-04-14 /pmc/articles/PMC6487166/ /pubmed/31161070 http://dx.doi.org/10.1155/2019/5735312 Text en Copyright © 2019 Janine Zee-Cheng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zee-Cheng, Janine
Fox, Thomas
Patel, Sonal
Abu-Sultaneh, Samer
Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess
title Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess
title_full Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess
title_fullStr Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess
title_full_unstemmed Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess
title_short Successful Use of Tissue Plasminogen Activator in an Adolescent Male with Pyogenic Liver Abscess
title_sort successful use of tissue plasminogen activator in an adolescent male with pyogenic liver abscess
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487166/
https://www.ncbi.nlm.nih.gov/pubmed/31161070
http://dx.doi.org/10.1155/2019/5735312
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