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MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined. In this study, reanalysis of data obtained from the Me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487172/ https://www.ncbi.nlm.nih.gov/pubmed/31111062 http://dx.doi.org/10.1155/2019/6394784 |
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author | Xing, Qianwei Xie, Huyang Zhu, Bingye Sun, Zhiwei Huang, Yeqing |
author_facet | Xing, Qianwei Xie, Huyang Zhu, Bingye Sun, Zhiwei Huang, Yeqing |
author_sort | Xing, Qianwei |
collection | PubMed |
description | Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined. In this study, reanalysis of data obtained from the Memorial Sloan Kettering Cancer Center showed that miR-455-5p can be used as biomarker for PCa diagnosis and predictor of poor prognosis. Functional assays indicated that miR-455-5p overexpression could suppress cellular proliferation, inhibit tumor growth, and trigger apoptosis by activating and cleaving caspase 3. We experimentally verified that miR-455-5p negatively regulated the C–C motif chemokine receptor 5 (CCR5). Overall, our data demonstrate that miR-455-5p suppressed PCa cellular proliferation and induced cell apoptosis by downregulating CCR5. Thus, miR-455-5p may be considered a new therapeutic strategy for PCa. |
format | Online Article Text |
id | pubmed-6487172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64871722019-05-20 MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 Xing, Qianwei Xie, Huyang Zhu, Bingye Sun, Zhiwei Huang, Yeqing Biomed Res Int Research Article Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined. In this study, reanalysis of data obtained from the Memorial Sloan Kettering Cancer Center showed that miR-455-5p can be used as biomarker for PCa diagnosis and predictor of poor prognosis. Functional assays indicated that miR-455-5p overexpression could suppress cellular proliferation, inhibit tumor growth, and trigger apoptosis by activating and cleaving caspase 3. We experimentally verified that miR-455-5p negatively regulated the C–C motif chemokine receptor 5 (CCR5). Overall, our data demonstrate that miR-455-5p suppressed PCa cellular proliferation and induced cell apoptosis by downregulating CCR5. Thus, miR-455-5p may be considered a new therapeutic strategy for PCa. Hindawi 2019-04-11 /pmc/articles/PMC6487172/ /pubmed/31111062 http://dx.doi.org/10.1155/2019/6394784 Text en Copyright © 2019 Qianwei Xing et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Xing, Qianwei Xie, Huyang Zhu, Bingye Sun, Zhiwei Huang, Yeqing MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 |
title | MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 |
title_full | MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 |
title_fullStr | MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 |
title_full_unstemmed | MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 |
title_short | MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 |
title_sort | mir-455-5p suppresses the progression of prostate cancer by targeting ccr5 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487172/ https://www.ncbi.nlm.nih.gov/pubmed/31111062 http://dx.doi.org/10.1155/2019/6394784 |
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