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MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5

Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined. In this study, reanalysis of data obtained from the Me...

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Detalles Bibliográficos
Autores principales: Xing, Qianwei, Xie, Huyang, Zhu, Bingye, Sun, Zhiwei, Huang, Yeqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487172/
https://www.ncbi.nlm.nih.gov/pubmed/31111062
http://dx.doi.org/10.1155/2019/6394784
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author Xing, Qianwei
Xie, Huyang
Zhu, Bingye
Sun, Zhiwei
Huang, Yeqing
author_facet Xing, Qianwei
Xie, Huyang
Zhu, Bingye
Sun, Zhiwei
Huang, Yeqing
author_sort Xing, Qianwei
collection PubMed
description Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined. In this study, reanalysis of data obtained from the Memorial Sloan Kettering Cancer Center showed that miR-455-5p can be used as biomarker for PCa diagnosis and predictor of poor prognosis. Functional assays indicated that miR-455-5p overexpression could suppress cellular proliferation, inhibit tumor growth, and trigger apoptosis by activating and cleaving caspase 3. We experimentally verified that miR-455-5p negatively regulated the C–C motif chemokine receptor 5 (CCR5). Overall, our data demonstrate that miR-455-5p suppressed PCa cellular proliferation and induced cell apoptosis by downregulating CCR5. Thus, miR-455-5p may be considered a new therapeutic strategy for PCa.
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spelling pubmed-64871722019-05-20 MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5 Xing, Qianwei Xie, Huyang Zhu, Bingye Sun, Zhiwei Huang, Yeqing Biomed Res Int Research Article Accumulated evidence indicates that miR-455-5p functions as tumor suppressor in the progression of various cancers. However, the mechanism through which miR-455-5p influences the tumorigenesis of human prostate cancer (PCa) remains undetermined. In this study, reanalysis of data obtained from the Memorial Sloan Kettering Cancer Center showed that miR-455-5p can be used as biomarker for PCa diagnosis and predictor of poor prognosis. Functional assays indicated that miR-455-5p overexpression could suppress cellular proliferation, inhibit tumor growth, and trigger apoptosis by activating and cleaving caspase 3. We experimentally verified that miR-455-5p negatively regulated the C–C motif chemokine receptor 5 (CCR5). Overall, our data demonstrate that miR-455-5p suppressed PCa cellular proliferation and induced cell apoptosis by downregulating CCR5. Thus, miR-455-5p may be considered a new therapeutic strategy for PCa. Hindawi 2019-04-11 /pmc/articles/PMC6487172/ /pubmed/31111062 http://dx.doi.org/10.1155/2019/6394784 Text en Copyright © 2019 Qianwei Xing et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xing, Qianwei
Xie, Huyang
Zhu, Bingye
Sun, Zhiwei
Huang, Yeqing
MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
title MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
title_full MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
title_fullStr MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
title_full_unstemmed MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
title_short MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5
title_sort mir-455-5p suppresses the progression of prostate cancer by targeting ccr5
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487172/
https://www.ncbi.nlm.nih.gov/pubmed/31111062
http://dx.doi.org/10.1155/2019/6394784
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