Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement

A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he...

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Detalles Bibliográficos
Autores principales: Kato, Takeharu, Itonaga, Hidehiro, Taguchi, Jun, Makiyama, Junya, Fujioka, Machiko, Taguchi, Masataka, Horai, Makiko, Sawayama, Yasushi, Niino, Daisuke, Imaizumi, Yoshitaka, Hata, Tomoko, Yoshida, Shinichiro, Sakamoto, Kana, Takeuchi, Kengo, Ohshima, Koichi, Miyazaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487276/
https://www.ncbi.nlm.nih.gov/pubmed/31061790
http://dx.doi.org/10.1016/j.lrr.2019.04.005
Descripción
Sumario:A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he underwent a second BMT from another unrelated donor, and experienced complete remission with grade II acute graft-versus-host disease and moderate chronic graft-versus-host disease. He remains alive in complete remission more than 71 months after the second BMT. These results suggested that donor change at the second transplantation may represent a considerable therapeutic option for patients with relapsed BPDCN.

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