Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination

It has been shown that CD40 is required for optimal B cell activation. Casitas-B-lineage lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, inhibits B cell activation. In this report, we demonstrate that CD40 stimulation markedly enhances IgM-induced B cell proliferation in wild-type (WT) mice,...

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Detalles Bibliográficos
Autores principales: Tang, Na, Yang, Lifen, Li, Dongdong, Liu, Rushi, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487278/
https://www.ncbi.nlm.nih.gov/pubmed/31061898
http://dx.doi.org/10.1016/j.bbrep.2019.100641

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