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Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics

Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwester...

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Autores principales: Esmaeilzadeh, Hossein, Farjadian, Shirin, Alyasin, Soheila, Nemati, Hamid, Nabavizadeh, Hesamodin, Esmaeilzadeh, Elmira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487414/
https://www.ncbi.nlm.nih.gov/pubmed/31089385
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author Esmaeilzadeh, Hossein
Farjadian, Shirin
Alyasin, Soheila
Nemati, Hamid
Nabavizadeh, Hesamodin
Esmaeilzadeh, Elmira
author_facet Esmaeilzadeh, Hossein
Farjadian, Shirin
Alyasin, Soheila
Nemati, Hamid
Nabavizadeh, Hesamodin
Esmaeilzadeh, Elmira
author_sort Esmaeilzadeh, Hossein
collection PubMed
description Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwestern of Iran from 2013 to 2017. Demographic data, past allergy and autoimmune history, clinical presentations, drugs confirmed to be the cause of SCAR as well as its therapy were reviewed for each patient. HLA-A and -B allele frequencies were determined in 40 of the patients using polymerase chain reaction based on sequence specific primers (PCR-SSP) and compared with 40 healthy individuals as control group. Sixty-one patients with mean age of 6 years old and boy to girl ratio was 1.2/1 in this study. The most common type of SCAR in our patients was Steven Johnson Syndrome (SJS)/Toxic Epidermal Necrosis (TEN) mainly caused by beta-lactam antibiotics. Carbamazepine was the second cause of drug–induced SCAR. Moreover, HLA-A*02:01 and A*51:01 were related to the increased risk of SCAR while A*11:01 seemed to be protective against SCAR. HLA-A*02:01, HLA-A*24:02, and HLA-B*51:01 showed associations to the increased risk of SJS. Based on our results, beta-lactam antibiotics and antiepileptic drugs are the most common causes of severe adverse drug reaction in southwestern Iranian pediatric patients. Moreover, some HLA-A alleles can influence risk of SCAR.
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spelling pubmed-64874142019-05-14 Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics Esmaeilzadeh, Hossein Farjadian, Shirin Alyasin, Soheila Nemati, Hamid Nabavizadeh, Hesamodin Esmaeilzadeh, Elmira Iran J Pharm Res Original Article Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwestern of Iran from 2013 to 2017. Demographic data, past allergy and autoimmune history, clinical presentations, drugs confirmed to be the cause of SCAR as well as its therapy were reviewed for each patient. HLA-A and -B allele frequencies were determined in 40 of the patients using polymerase chain reaction based on sequence specific primers (PCR-SSP) and compared with 40 healthy individuals as control group. Sixty-one patients with mean age of 6 years old and boy to girl ratio was 1.2/1 in this study. The most common type of SCAR in our patients was Steven Johnson Syndrome (SJS)/Toxic Epidermal Necrosis (TEN) mainly caused by beta-lactam antibiotics. Carbamazepine was the second cause of drug–induced SCAR. Moreover, HLA-A*02:01 and A*51:01 were related to the increased risk of SCAR while A*11:01 seemed to be protective against SCAR. HLA-A*02:01, HLA-A*24:02, and HLA-B*51:01 showed associations to the increased risk of SJS. Based on our results, beta-lactam antibiotics and antiepileptic drugs are the most common causes of severe adverse drug reaction in southwestern Iranian pediatric patients. Moreover, some HLA-A alleles can influence risk of SCAR. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC6487414/ /pubmed/31089385 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Esmaeilzadeh, Hossein
Farjadian, Shirin
Alyasin, Soheila
Nemati, Hamid
Nabavizadeh, Hesamodin
Esmaeilzadeh, Elmira
Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
title Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
title_full Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
title_fullStr Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
title_full_unstemmed Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
title_short Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
title_sort epidemiology of severe cutaneous adverse drug reaction and its hla association among pediatrics
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487414/
https://www.ncbi.nlm.nih.gov/pubmed/31089385
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