Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite

A high sensitive electrochemical nanostructure sensor based on graphene oxide/Fe(3)O(4)@SiO(2) nanocomposite modified graphite screen printed electrode (GO/Fe(3)O(4)@SiO(2)/SPE) has been developed for trace analysis of acetaminophen. The electrochemical study of the modified electrode, as well as it...

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Autores principales: Beitollahi, Hadi, Garkani-Nejad, Fariba, Tajik, Somayeh, Ganjali, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487427/
https://www.ncbi.nlm.nih.gov/pubmed/31089346
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author Beitollahi, Hadi
Garkani-Nejad, Fariba
Tajik, Somayeh
Ganjali, Mohammad Reza
author_facet Beitollahi, Hadi
Garkani-Nejad, Fariba
Tajik, Somayeh
Ganjali, Mohammad Reza
author_sort Beitollahi, Hadi
collection PubMed
description A high sensitive electrochemical nanostructure sensor based on graphene oxide/Fe(3)O(4)@SiO(2) nanocomposite modified graphite screen printed electrode (GO/Fe(3)O(4)@SiO(2)/SPE) has been developed for trace analysis of acetaminophen. The electrochemical study of the modified electrode, as well as its efficiency for simultaneous voltammetric oxidation of acetaminophen and tryptophan is described. Compared with bare SPE the GO/Fe(3)O(4)@SiO(2)/SPE exhibited excellent electrocatalytic activity toward the oxidation of acetaminophen. The plot of catalytic current versus acetaminophen concentration showed a linear segment in the concentration range 0.5 to 100.0 µM. The detection limit of 0.1 µM was obtained using calibration plot. Also the anodic peaks of acetaminophen and tryptophan in their mixture can be well separated. The GO/Fe(3)O(4)@SiO(2)/SPE has been successfully applied and validated by analyzing acetaminophen and tryptophan in urine and pharmaceutical samples.
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spelling pubmed-64874272019-05-14 Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite Beitollahi, Hadi Garkani-Nejad, Fariba Tajik, Somayeh Ganjali, Mohammad Reza Iran J Pharm Res Original Article A high sensitive electrochemical nanostructure sensor based on graphene oxide/Fe(3)O(4)@SiO(2) nanocomposite modified graphite screen printed electrode (GO/Fe(3)O(4)@SiO(2)/SPE) has been developed for trace analysis of acetaminophen. The electrochemical study of the modified electrode, as well as its efficiency for simultaneous voltammetric oxidation of acetaminophen and tryptophan is described. Compared with bare SPE the GO/Fe(3)O(4)@SiO(2)/SPE exhibited excellent electrocatalytic activity toward the oxidation of acetaminophen. The plot of catalytic current versus acetaminophen concentration showed a linear segment in the concentration range 0.5 to 100.0 µM. The detection limit of 0.1 µM was obtained using calibration plot. Also the anodic peaks of acetaminophen and tryptophan in their mixture can be well separated. The GO/Fe(3)O(4)@SiO(2)/SPE has been successfully applied and validated by analyzing acetaminophen and tryptophan in urine and pharmaceutical samples. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC6487427/ /pubmed/31089346 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Beitollahi, Hadi
Garkani-Nejad, Fariba
Tajik, Somayeh
Ganjali, Mohammad Reza
Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite
title Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite
title_full Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite
title_fullStr Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite
title_full_unstemmed Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite
title_short Voltammetric Determination of Acetaminophen and Tryptophan Using a Graphite Screen Printed Electrode Modified with Functionalized Graphene Oxide Nanosheets Within a Fe(3)O(4)@SiO(2 )Nanocomposite
title_sort voltammetric determination of acetaminophen and tryptophan using a graphite screen printed electrode modified with functionalized graphene oxide nanosheets within a fe(3)o(4)@sio(2 )nanocomposite
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487427/
https://www.ncbi.nlm.nih.gov/pubmed/31089346
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