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New Diterpenoids from the Aerial Parts of Salvia reuterana
The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β, 14α-dihydroxy-15-acetoxysclareol (1), and 14α, 15- dihydroxy scla...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487430/ https://www.ncbi.nlm.nih.gov/pubmed/31089375 |
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author | Moridi Farimani, Mahdi Miran, Mansour Nejad Ebrahimi, Samad |
author_facet | Moridi Farimani, Mahdi Miran, Mansour Nejad Ebrahimi, Samad |
author_sort | Moridi Farimani, Mahdi |
collection | PubMed |
description | The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β, 14α-dihydroxy-15-acetoxysclareol (1), and 14α, 15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly by 1D and 2D NMR spectroscopic techniques, including (1)H-(1)H COSY, HSQC and HMBC methods and HR-ESI-TOFMS spectral data. Compound 1 and 2 were tested for their inhibitory activity toward HeLa and MCF-7 cell lines. Our results showed that S. reuterana is a rich source of labdane diterpenoids. These compounds are rather rare in Salvia species, although they are frequently found in other genera of the Lamiaceae. S. reuterana is a new source of these diterpenoids. |
format | Online Article Text |
id | pubmed-6487430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-64874302019-05-14 New Diterpenoids from the Aerial Parts of Salvia reuterana Moridi Farimani, Mahdi Miran, Mansour Nejad Ebrahimi, Samad Iran J Pharm Res Original Article The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β, 14α-dihydroxy-15-acetoxysclareol (1), and 14α, 15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly by 1D and 2D NMR spectroscopic techniques, including (1)H-(1)H COSY, HSQC and HMBC methods and HR-ESI-TOFMS spectral data. Compound 1 and 2 were tested for their inhibitory activity toward HeLa and MCF-7 cell lines. Our results showed that S. reuterana is a rich source of labdane diterpenoids. These compounds are rather rare in Salvia species, although they are frequently found in other genera of the Lamiaceae. S. reuterana is a new source of these diterpenoids. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC6487430/ /pubmed/31089375 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Moridi Farimani, Mahdi Miran, Mansour Nejad Ebrahimi, Samad New Diterpenoids from the Aerial Parts of Salvia reuterana |
title | New Diterpenoids from the Aerial Parts of Salvia reuterana |
title_full | New Diterpenoids from the Aerial Parts of Salvia reuterana |
title_fullStr | New Diterpenoids from the Aerial Parts of Salvia reuterana |
title_full_unstemmed | New Diterpenoids from the Aerial Parts of Salvia reuterana |
title_short | New Diterpenoids from the Aerial Parts of Salvia reuterana |
title_sort | new diterpenoids from the aerial parts of salvia reuterana |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487430/ https://www.ncbi.nlm.nih.gov/pubmed/31089375 |
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