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UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.)
Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of Egypt. The current study aimed at UPLC/PDA/ESI-MS(n )qualitative chemical profiling of the phyto-constituents underlining both antioxidant and cytotoxic activities of the bio-active fraction in comparison wit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487433/ https://www.ncbi.nlm.nih.gov/pubmed/31089377 |
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author | Handoussa, Heba AbdAllah, Walid AbdelMohsen, Mona |
author_facet | Handoussa, Heba AbdAllah, Walid AbdelMohsen, Mona |
author_sort | Handoussa, Heba |
collection | PubMed |
description | Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of Egypt. The current study aimed at UPLC/PDA/ESI-MS(n )qualitative chemical profiling of the phyto-constituents underlining both antioxidant and cytotoxic activities of the bio-active fraction in comparison with the other fractions. It resulted in detection of several related compounds to prenylated flavonol icariin as a first report in this species. Results showed that ethyl acetate exhibits an appreciable antioxidant activity using in-vitro DPPH assay with percentage of 82.35% and remarkable anticancer capacity against most common types of cancer in Egypt; breast (MCF-7), human prostate (PC-3) cancer cell lines, and human lung carcinoma (A-549) with IC(50) 43.1± 2 µg/mL, 115±5 µg/ml, and 53.3±3 µg/mL respectively. These findings point out the appropriate solvent for extraction of the bio-phenolics with this halophyte which is a considerable source of remarkable potential secondary metabolites that exhibit original and interesting anticancer capacity. |
format | Online Article Text |
id | pubmed-6487433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-64874332019-05-14 UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) Handoussa, Heba AbdAllah, Walid AbdelMohsen, Mona Iran J Pharm Res Original Article Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of Egypt. The current study aimed at UPLC/PDA/ESI-MS(n )qualitative chemical profiling of the phyto-constituents underlining both antioxidant and cytotoxic activities of the bio-active fraction in comparison with the other fractions. It resulted in detection of several related compounds to prenylated flavonol icariin as a first report in this species. Results showed that ethyl acetate exhibits an appreciable antioxidant activity using in-vitro DPPH assay with percentage of 82.35% and remarkable anticancer capacity against most common types of cancer in Egypt; breast (MCF-7), human prostate (PC-3) cancer cell lines, and human lung carcinoma (A-549) with IC(50) 43.1± 2 µg/mL, 115±5 µg/ml, and 53.3±3 µg/mL respectively. These findings point out the appropriate solvent for extraction of the bio-phenolics with this halophyte which is a considerable source of remarkable potential secondary metabolites that exhibit original and interesting anticancer capacity. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC6487433/ /pubmed/31089377 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Handoussa, Heba AbdAllah, Walid AbdelMohsen, Mona UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) |
title | UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) |
title_full | UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) |
title_fullStr | UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) |
title_full_unstemmed | UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) |
title_short | UPLC–ESI-PDA–Ms(n) Profiling Of Phenolics Involved In Biological Activities Of The Medicinal Plant Halocnemum Strobilaceum (Pall.) |
title_sort | uplc–esi-pda–ms(n) profiling of phenolics involved in biological activities of the medicinal plant halocnemum strobilaceum (pall.) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487433/ https://www.ncbi.nlm.nih.gov/pubmed/31089377 |
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