N-Terminal Domain of Fragile Histidine Triad Exerts Potent Cytotoxic Effect in HT1080 Cells and Increases Doxorubicin Cytotoxicity

Fragile histidine triad (FHIT) serves a critical function as a tumor suppressor that inhibits p53 degradation by mouse double minute 2 (MDM2). The functional domains of FHIT involved in tumor inhibition was interpreted. In-silico screening data were employed to construct truncated forms of FHIT to a...

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Detalles Bibliográficos
Autores principales: Eslamparast, Ameneh, Abbasgholizadeh, Reza, Ostad, Seyed Nasser, Gharghabi, Mehdi, Ghahremani, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487436/
https://www.ncbi.nlm.nih.gov/pubmed/31089360

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