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Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data
Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study – of hair samples, shed deciduous (baby) teeth, and body fluids – will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key st...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487488/ https://www.ncbi.nlm.nih.gov/pubmed/29606560 http://dx.doi.org/10.1016/j.dcn.2018.03.005 |
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author | Uban, Kristina A. Horton, Megan K. Jacobus, Joanna Heyser, Charles Thompson, Wesley K. Tapert, Susan F. Madden, Pamela A.F. Sowell, Elizabeth R. |
author_facet | Uban, Kristina A. Horton, Megan K. Jacobus, Joanna Heyser, Charles Thompson, Wesley K. Tapert, Susan F. Madden, Pamela A.F. Sowell, Elizabeth R. |
author_sort | Uban, Kristina A. |
collection | PubMed |
description | Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study – of hair samples, shed deciduous (baby) teeth, and body fluids – will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations. |
format | Online Article Text |
id | pubmed-6487488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-64874882019-04-29 Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data Uban, Kristina A. Horton, Megan K. Jacobus, Joanna Heyser, Charles Thompson, Wesley K. Tapert, Susan F. Madden, Pamela A.F. Sowell, Elizabeth R. Dev Cogn Neurosci Article Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study – of hair samples, shed deciduous (baby) teeth, and body fluids – will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations. Elsevier 2018-03-16 /pmc/articles/PMC6487488/ /pubmed/29606560 http://dx.doi.org/10.1016/j.dcn.2018.03.005 Text en © 2018 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Uban, Kristina A. Horton, Megan K. Jacobus, Joanna Heyser, Charles Thompson, Wesley K. Tapert, Susan F. Madden, Pamela A.F. Sowell, Elizabeth R. Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
title | Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
title_full | Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
title_fullStr | Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
title_full_unstemmed | Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
title_short | Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data |
title_sort | biospecimens and the abcd study: rationale, methods of collection, measurement and early data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487488/ https://www.ncbi.nlm.nih.gov/pubmed/29606560 http://dx.doi.org/10.1016/j.dcn.2018.03.005 |
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