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Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies

RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear. In an unbiased screen in Drosophila for RBPs that genetically interact with TDP-43, we found that downregulation of the mRNA ex...

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Detalles Bibliográficos
Autores principales:	Berson, Amit, Goodman, Lindsey D., Sartoris, Ashley N., Otte, Charlton G., Aykit, James A., Lee, Virginia M.-Y., Trojanowski, John Q., Bonini, Nancy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487524/ https://www.ncbi.nlm.nih.gov/pubmed/31036086 http://dx.doi.org/10.1186/s40478-019-0710-x

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