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Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age

IMPORTANCE: Both fetal and infant growth influence obesity later in life. The association of longitudinal fetal and infant growth patterns with organ fat is unknown. OBJECTIVE: To examine the associations of fetal and infant weight change with general, visceral, and organ adiposity at school age. DE...

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Autores principales: Vogelezang, Suzanne, Santos, Susana, Toemen, Liza, Oei, Edwin H. G., Felix, Janine F., Jaddoe, Vincent W. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487630/
https://www.ncbi.nlm.nih.gov/pubmed/31026028
http://dx.doi.org/10.1001/jamanetworkopen.2019.2843
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author Vogelezang, Suzanne
Santos, Susana
Toemen, Liza
Oei, Edwin H. G.
Felix, Janine F.
Jaddoe, Vincent W. V.
author_facet Vogelezang, Suzanne
Santos, Susana
Toemen, Liza
Oei, Edwin H. G.
Felix, Janine F.
Jaddoe, Vincent W. V.
author_sort Vogelezang, Suzanne
collection PubMed
description IMPORTANCE: Both fetal and infant growth influence obesity later in life. The association of longitudinal fetal and infant growth patterns with organ fat is unknown. OBJECTIVE: To examine the associations of fetal and infant weight change with general, visceral, and organ adiposity at school age. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was embedded in the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. Pregnant women with a delivery date between April 2002 and January 2006 were eligible to participate. Follow-up measurements were performed for 3205 children. Data analysis of this population was performed from July 26, 2018, to February 7, 2019. EXPOSURES: Fetal weight was estimated in the second and third trimester of pregnancy. Infant weight was measured at 6, 12, and 24 months. Fetal and infant weight acceleration or deceleration were defined as a change in standard deviation scores greater than 0.67 between 2 ages. MAIN OUTCOMES AND MEASURES: Visceral fat index, pericardial fat index, and liver fat fraction were measured by magnetic resonance imaging. RESULTS: The sample consisted of 3205 children (1632 girls [50.9%]; mean [SD] age, 9.8 [0.3] years). Children born small for gestational age had the lowest median body mass index compared with children born appropriate for gestational age and large for gestational age (16.4 [90% range, 14.1-23.6] vs 16.9 [90% range, 14.4-22.8] vs 17.4 [90% range, 14.9-22.7]). Compared with children with normal fetal and infant growth (533 of 2370 [22.5%]), those with fetal weight deceleration followed by infant weight acceleration (263 of 2370 [11.1%]) had the highest visceral fat index (standard deviation scores, 0.18; 95% CI, 0.03-0.33; P = .02) and liver fat fraction (standard deviation scores, 0.34; 95% CI, 0.20-0.48; P < .001). CONCLUSIONS AND RELEVANCE: Fetal and infant weight change patterns were both associated with childhood body fat, but weight change patterns in infancy tended to have larger effects. Fetal growth restriction followed by infant growth acceleration was associated with increased visceral and liver fat.
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spelling pubmed-64876302019-05-03 Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age Vogelezang, Suzanne Santos, Susana Toemen, Liza Oei, Edwin H. G. Felix, Janine F. Jaddoe, Vincent W. V. JAMA Netw Open Original Investigation IMPORTANCE: Both fetal and infant growth influence obesity later in life. The association of longitudinal fetal and infant growth patterns with organ fat is unknown. OBJECTIVE: To examine the associations of fetal and infant weight change with general, visceral, and organ adiposity at school age. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was embedded in the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. Pregnant women with a delivery date between April 2002 and January 2006 were eligible to participate. Follow-up measurements were performed for 3205 children. Data analysis of this population was performed from July 26, 2018, to February 7, 2019. EXPOSURES: Fetal weight was estimated in the second and third trimester of pregnancy. Infant weight was measured at 6, 12, and 24 months. Fetal and infant weight acceleration or deceleration were defined as a change in standard deviation scores greater than 0.67 between 2 ages. MAIN OUTCOMES AND MEASURES: Visceral fat index, pericardial fat index, and liver fat fraction were measured by magnetic resonance imaging. RESULTS: The sample consisted of 3205 children (1632 girls [50.9%]; mean [SD] age, 9.8 [0.3] years). Children born small for gestational age had the lowest median body mass index compared with children born appropriate for gestational age and large for gestational age (16.4 [90% range, 14.1-23.6] vs 16.9 [90% range, 14.4-22.8] vs 17.4 [90% range, 14.9-22.7]). Compared with children with normal fetal and infant growth (533 of 2370 [22.5%]), those with fetal weight deceleration followed by infant weight acceleration (263 of 2370 [11.1%]) had the highest visceral fat index (standard deviation scores, 0.18; 95% CI, 0.03-0.33; P = .02) and liver fat fraction (standard deviation scores, 0.34; 95% CI, 0.20-0.48; P < .001). CONCLUSIONS AND RELEVANCE: Fetal and infant weight change patterns were both associated with childhood body fat, but weight change patterns in infancy tended to have larger effects. Fetal growth restriction followed by infant growth acceleration was associated with increased visceral and liver fat. American Medical Association 2019-04-26 /pmc/articles/PMC6487630/ /pubmed/31026028 http://dx.doi.org/10.1001/jamanetworkopen.2019.2843 Text en Copyright 2019 Vogelezang S et al. JAMA Network Open. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Vogelezang, Suzanne
Santos, Susana
Toemen, Liza
Oei, Edwin H. G.
Felix, Janine F.
Jaddoe, Vincent W. V.
Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age
title Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age
title_full Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age
title_fullStr Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age
title_full_unstemmed Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age
title_short Associations of Fetal and Infant Weight Change With General, Visceral, and Organ Adiposity at School Age
title_sort associations of fetal and infant weight change with general, visceral, and organ adiposity at school age
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487630/
https://www.ncbi.nlm.nih.gov/pubmed/31026028
http://dx.doi.org/10.1001/jamanetworkopen.2019.2843
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