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Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer
Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487687/ https://www.ncbi.nlm.nih.gov/pubmed/30927479 http://dx.doi.org/10.1002/1878-0261.12484 |
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author | Link, Theresa Kuhlmann, Jan Dominik Kobelt, Dennis Herrmann, Pia Vassileva, Yana D. Kramer, Michael Frank, Kerstin Göckenjan, Maren Wimberger, Pauline Stein, Ulrike |
author_facet | Link, Theresa Kuhlmann, Jan Dominik Kobelt, Dennis Herrmann, Pia Vassileva, Yana D. Kramer, Michael Frank, Kerstin Göckenjan, Maren Wimberger, Pauline Stein, Ulrike |
author_sort | Link, Theresa |
collection | PubMed |
description | Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT‐qPCR and digital droplet PCR, respectively. MACC1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls (P = 0.024; P < 0.001). At primary diagnosis, high levels of MACC1 or S100A4 correlated with advanced FIGO stage (P = 0.042; P = 0.008), predicted suboptimal debulking surgery and indicated shorter progression‐free survival (PFS; P = 0.003; P = 0.001) and overall survival (OS; P = 0.001; P = 0.002). This is the first study in ovarian cancer to propose circulating MACC1 and S100A4 transcripts as potential liquid biopsy markers. |
format | Online Article Text |
id | pubmed-6487687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64876872019-05-07 Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer Link, Theresa Kuhlmann, Jan Dominik Kobelt, Dennis Herrmann, Pia Vassileva, Yana D. Kramer, Michael Frank, Kerstin Göckenjan, Maren Wimberger, Pauline Stein, Ulrike Mol Oncol Research Articles Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT‐qPCR and digital droplet PCR, respectively. MACC1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls (P = 0.024; P < 0.001). At primary diagnosis, high levels of MACC1 or S100A4 correlated with advanced FIGO stage (P = 0.042; P = 0.008), predicted suboptimal debulking surgery and indicated shorter progression‐free survival (PFS; P = 0.003; P = 0.001) and overall survival (OS; P = 0.001; P = 0.002). This is the first study in ovarian cancer to propose circulating MACC1 and S100A4 transcripts as potential liquid biopsy markers. John Wiley and Sons Inc. 2019-04-15 2019-05 /pmc/articles/PMC6487687/ /pubmed/30927479 http://dx.doi.org/10.1002/1878-0261.12484 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Link, Theresa Kuhlmann, Jan Dominik Kobelt, Dennis Herrmann, Pia Vassileva, Yana D. Kramer, Michael Frank, Kerstin Göckenjan, Maren Wimberger, Pauline Stein, Ulrike Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer |
title | Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer |
title_full | Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer |
title_fullStr | Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer |
title_full_unstemmed | Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer |
title_short | Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer |
title_sort | clinical relevance of circulating macc1 and s100a4 transcripts for ovarian cancer |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487687/ https://www.ncbi.nlm.nih.gov/pubmed/30927479 http://dx.doi.org/10.1002/1878-0261.12484 |
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