The role of lysosomes and autophagosomes in frontotemporal lobar degeneration

INTRODUCTION: Cell biological and genetic evidence implicate failures in degrading aggregating proteins, such as tau and TDP‐43, through the autophagy or lysosomal pathways in the pathogenesis of frontotemporal lobar degeneration (FTLD). METHODS: We investigated changes in the degradative pathways i...

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Detalles Bibliográficos
Autores principales: Bain, H. D. C., Davidson, Y. S., Robinson, A. C., Ryan, S., Rollinson, S., Richardson, A., Jones, M., Snowden, J. S., Pickering‐Brown, S., Mann, D. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487817/
https://www.ncbi.nlm.nih.gov/pubmed/29790198
http://dx.doi.org/10.1111/nan.12500

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