Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells

Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐...

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Autores principales: Chen, Changjun, Wang, Songgang, Chen, Jiying, Liu, Xiaolin, Zhang, Mengchen, Wang, Xi, Xu, Weihua, Zhang, Yayun, Li, Hao, Pan, Xin, Si, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487832/
https://www.ncbi.nlm.nih.gov/pubmed/30972964
http://dx.doi.org/10.1002/2211-5463.12622
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author Chen, Changjun
Wang, Songgang
Chen, Jiying
Liu, Xiaolin
Zhang, Mengchen
Wang, Xi
Xu, Weihua
Zhang, Yayun
Li, Hao
Pan, Xin
Si, Meng
author_facet Chen, Changjun
Wang, Songgang
Chen, Jiying
Liu, Xiaolin
Zhang, Mengchen
Wang, Xi
Xu, Weihua
Zhang, Yayun
Li, Hao
Pan, Xin
Si, Meng
author_sort Chen, Changjun
collection PubMed
description Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐inflammatory high mobility group protein 1 (HMGB1). Here, we report that escin can suppress (a) HMGB1‐induced overexpression of the aquaporin‐1 (AQP1) water channel in endothelial cells and (b) HMGB1‐induced increases in endothelial cell permeability. This is the first report that escin inhibits AQP1 and alleviates barrier dysfunction in HMGB1‐induced inflammatory response.
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spelling pubmed-64878322019-05-06 Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells Chen, Changjun Wang, Songgang Chen, Jiying Liu, Xiaolin Zhang, Mengchen Wang, Xi Xu, Weihua Zhang, Yayun Li, Hao Pan, Xin Si, Meng FEBS Open Bio Research Articles Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐inflammatory high mobility group protein 1 (HMGB1). Here, we report that escin can suppress (a) HMGB1‐induced overexpression of the aquaporin‐1 (AQP1) water channel in endothelial cells and (b) HMGB1‐induced increases in endothelial cell permeability. This is the first report that escin inhibits AQP1 and alleviates barrier dysfunction in HMGB1‐induced inflammatory response. John Wiley and Sons Inc. 2019-04-10 /pmc/articles/PMC6487832/ /pubmed/30972964 http://dx.doi.org/10.1002/2211-5463.12622 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Chen, Changjun
Wang, Songgang
Chen, Jiying
Liu, Xiaolin
Zhang, Mengchen
Wang, Xi
Xu, Weihua
Zhang, Yayun
Li, Hao
Pan, Xin
Si, Meng
Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
title Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
title_full Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
title_fullStr Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
title_full_unstemmed Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
title_short Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
title_sort escin suppresses hmgb1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487832/
https://www.ncbi.nlm.nih.gov/pubmed/30972964
http://dx.doi.org/10.1002/2211-5463.12622
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