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Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer

Altered expression of long non‐coding RNAs (lncRNAs) has been reported in many malignancies, including prostate cancer. However, the role of lncRNA MNX1‐AS1 in prostate cancer has not been reported. Here, we report that MNX1‐AS1 is expressed in prostate cancer tissues and cells and that siRNA‐mediat...

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Detalles Bibliográficos
Autores principales: Li, Zongwu, Wang, Fangfei, Zhang, Shibao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487840/
https://www.ncbi.nlm.nih.gov/pubmed/30980513
http://dx.doi.org/10.1002/2211-5463.12611
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author Li, Zongwu
Wang, Fangfei
Zhang, Shibao
author_facet Li, Zongwu
Wang, Fangfei
Zhang, Shibao
author_sort Li, Zongwu
collection PubMed
description Altered expression of long non‐coding RNAs (lncRNAs) has been reported in many malignancies, including prostate cancer. However, the role of lncRNA MNX1‐AS1 in prostate cancer has not been reported. Here, we report that MNX1‐AS1 is expressed in prostate cancer tissues and cells and that siRNA‐mediated knockdown of MNX1‐AS1 inhibits proliferation, migration, and invasion of prostate cancer DU145 and PC3 cells. In addition, down‐regulation of MNX1‐AS1 decreased expression of proliferating cell nuclear antigen, PH‐3, N‐cadherin, and vimentin, but enhanced expression of E‐cadherin. In conclusion, this is the first report that knockdown of MNX1‐AS1 suppresses prostate cancer cell proliferation, migration, and invasion. We believe that MNX1‐AS1 may be a potential new therapeutic target for prostate cancer patients.
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spelling pubmed-64878402019-05-06 Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer Li, Zongwu Wang, Fangfei Zhang, Shibao FEBS Open Bio Research Articles Altered expression of long non‐coding RNAs (lncRNAs) has been reported in many malignancies, including prostate cancer. However, the role of lncRNA MNX1‐AS1 in prostate cancer has not been reported. Here, we report that MNX1‐AS1 is expressed in prostate cancer tissues and cells and that siRNA‐mediated knockdown of MNX1‐AS1 inhibits proliferation, migration, and invasion of prostate cancer DU145 and PC3 cells. In addition, down‐regulation of MNX1‐AS1 decreased expression of proliferating cell nuclear antigen, PH‐3, N‐cadherin, and vimentin, but enhanced expression of E‐cadherin. In conclusion, this is the first report that knockdown of MNX1‐AS1 suppresses prostate cancer cell proliferation, migration, and invasion. We believe that MNX1‐AS1 may be a potential new therapeutic target for prostate cancer patients. John Wiley and Sons Inc. 2019-04-13 /pmc/articles/PMC6487840/ /pubmed/30980513 http://dx.doi.org/10.1002/2211-5463.12611 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Li, Zongwu
Wang, Fangfei
Zhang, Shibao
Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer
title Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer
title_full Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer
title_fullStr Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer
title_full_unstemmed Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer
title_short Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer
title_sort knockdown of lncrna mnx1‐as1 suppresses cell proliferation, migration, and invasion in prostate cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487840/
https://www.ncbi.nlm.nih.gov/pubmed/30980513
http://dx.doi.org/10.1002/2211-5463.12611
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