Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF‐κB/COX‐2‐mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma

Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and biological activities, but its role in glioblastoma (GBM) treatment is still unknown. The aim of the current study was to investigate the antiglioma effects of IATL and to explore the underlying molecular m...

Descripción completa

Detalles Bibliográficos
Autores principales: Xing, Jin‐Shan, Wang, Xun, Lan, Yu‐Long, Lou, Jia‐Cheng, Ma, Binbin, Zhu, Tingzhun, Zhang, Hongqiang, Wang, Dongsheng, Yu, Zhikuan, Yuan, Zhongbo, Li, Xin‐Yu, Zhang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488112/
https://www.ncbi.nlm.nih.gov/pubmed/30740911
http://dx.doi.org/10.1002/cam4.2013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488112/
https://www.ncbi.nlm.nih.gov/pubmed/30740911
http://dx.doi.org/10.1002/cam4.2013

Ejemplares similares