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Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF‐κB/COX‐2‐mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma
Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and biological activities, but its role in glioblastoma (GBM) treatment is still unknown. The aim of the current study was to investigate the antiglioma effects of IATL and to explore the underlying molecular m...
Autores principales: | Xing, Jin‐Shan, Wang, Xun, Lan, Yu‐Long, Lou, Jia‐Cheng, Ma, Binbin, Zhu, Tingzhun, Zhang, Hongqiang, Wang, Dongsheng, Yu, Zhikuan, Yuan, Zhongbo, Li, Xin‐Yu, Zhang, Bo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488112/ https://www.ncbi.nlm.nih.gov/pubmed/30740911 http://dx.doi.org/10.1002/cam4.2013 |
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