Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker

Antibody‐drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target‐killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we developed a novel ADC (ZV0508) that targets 5T4 oncofetal antigen...

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Detalles Bibliográficos
Autores principales: Shi, Baoying, Wu, Min, Li, Zhaohui, Xie, Zhangming, Wei, Xiaoyue, Fan, Jiansheng, Xu, Yingchun, Ding, Ding, Akash, Sajid Hamid, Chen, Shuqing, Cao, Sheldon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488119/
https://www.ncbi.nlm.nih.gov/pubmed/30843650
http://dx.doi.org/10.1002/cam4.2066

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