Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy

Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that perform as mediators in the tumor niche and play several roles in tumorigenesis, angiogenesis, and metastasis. In contrast, there are other studies su...

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Autores principales: Vakhshiteh, Faezeh, Atyabi, Fatemeh, Ostad, Seyed Nasser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488158/
https://www.ncbi.nlm.nih.gov/pubmed/31114198
http://dx.doi.org/10.2147/IJN.S200036
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author Vakhshiteh, Faezeh
Atyabi, Fatemeh
Ostad, Seyed Nasser
author_facet Vakhshiteh, Faezeh
Atyabi, Fatemeh
Ostad, Seyed Nasser
author_sort Vakhshiteh, Faezeh
collection PubMed
description Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that perform as mediators in the tumor niche and play several roles in tumorigenesis, angiogenesis, and metastasis. In contrast, there are other studies supporting the tumor-suppressing effects of MSC-derived exosomes. Therefore, the exact association of MSC exosomes and tumor cells remains open to debate. This review aimed to demonstrate the present knowledge of MSC-derived exosomes in cancer research and to illustrate current approaches to make use of modified exosomes as a platform in therapeutic strategies in cancer.
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spelling pubmed-64881582019-05-21 Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy Vakhshiteh, Faezeh Atyabi, Fatemeh Ostad, Seyed Nasser Int J Nanomedicine Review Mesenchymal stem cells (MSCs) are multipotent stromal cells present in various adult tissues. Several studies suggest that MSCs secrete exosomes that perform as mediators in the tumor niche and play several roles in tumorigenesis, angiogenesis, and metastasis. In contrast, there are other studies supporting the tumor-suppressing effects of MSC-derived exosomes. Therefore, the exact association of MSC exosomes and tumor cells remains open to debate. This review aimed to demonstrate the present knowledge of MSC-derived exosomes in cancer research and to illustrate current approaches to make use of modified exosomes as a platform in therapeutic strategies in cancer. Dove Medical Press 2019-04-23 /pmc/articles/PMC6488158/ /pubmed/31114198 http://dx.doi.org/10.2147/IJN.S200036 Text en © 2019 Vakhshiteh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Vakhshiteh, Faezeh
Atyabi, Fatemeh
Ostad, Seyed Nasser
Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_full Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_fullStr Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_full_unstemmed Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_short Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
title_sort mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488158/
https://www.ncbi.nlm.nih.gov/pubmed/31114198
http://dx.doi.org/10.2147/IJN.S200036
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