Detection of N(6)-methyladenosine modification residues (Review)

Among a number of mRNA modifications, N(6)-methyladenosine (m(6)A) modification is the most common type in eukaryotes and nuclear-replicating viruses. m(6)A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m(6)A...

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Autores principales: Zhu, Wei, Wang, Jing-Zi, Xu, Zhiqiang, Cao, Mengda, Hu, Qiaoli, Pan, Chen, Guo, Miao, Wei, Ji-Fu, Yang, Haiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488182/
https://www.ncbi.nlm.nih.gov/pubmed/31017262
http://dx.doi.org/10.3892/ijmm.2019.4169
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author Zhu, Wei
Wang, Jing-Zi
Xu, Zhiqiang
Cao, Mengda
Hu, Qiaoli
Pan, Chen
Guo, Miao
Wei, Ji-Fu
Yang, Haiwei
author_facet Zhu, Wei
Wang, Jing-Zi
Xu, Zhiqiang
Cao, Mengda
Hu, Qiaoli
Pan, Chen
Guo, Miao
Wei, Ji-Fu
Yang, Haiwei
author_sort Zhu, Wei
collection PubMed
description Among a number of mRNA modifications, N(6)-methyladenosine (m(6)A) modification is the most common type in eukaryotes and nuclear-replicating viruses. m(6)A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m(6)A methyltransferases are essential during RNA modifications, the biological functions of m(6)A and the underlying mechanisms remain to be fully elucidated, predominantly due to the limited detection methods for m(6)A. In the present review, the currently available m(6)A detection methods and the respective scope of their applications are presented to facilitate the further investigation of the roles of m(6)A in biological process.
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spelling pubmed-64881822019-06-11 Detection of N(6)-methyladenosine modification residues (Review) Zhu, Wei Wang, Jing-Zi Xu, Zhiqiang Cao, Mengda Hu, Qiaoli Pan, Chen Guo, Miao Wei, Ji-Fu Yang, Haiwei Int J Mol Med Articles Among a number of mRNA modifications, N(6)-methyladenosine (m(6)A) modification is the most common type in eukaryotes and nuclear-replicating viruses. m(6)A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m(6)A methyltransferases are essential during RNA modifications, the biological functions of m(6)A and the underlying mechanisms remain to be fully elucidated, predominantly due to the limited detection methods for m(6)A. In the present review, the currently available m(6)A detection methods and the respective scope of their applications are presented to facilitate the further investigation of the roles of m(6)A in biological process. D.A. Spandidos 2019-06 2019-04-18 /pmc/articles/PMC6488182/ /pubmed/31017262 http://dx.doi.org/10.3892/ijmm.2019.4169 Text en Copyright: © Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhu, Wei
Wang, Jing-Zi
Xu, Zhiqiang
Cao, Mengda
Hu, Qiaoli
Pan, Chen
Guo, Miao
Wei, Ji-Fu
Yang, Haiwei
Detection of N(6)-methyladenosine modification residues (Review)
title Detection of N(6)-methyladenosine modification residues (Review)
title_full Detection of N(6)-methyladenosine modification residues (Review)
title_fullStr Detection of N(6)-methyladenosine modification residues (Review)
title_full_unstemmed Detection of N(6)-methyladenosine modification residues (Review)
title_short Detection of N(6)-methyladenosine modification residues (Review)
title_sort detection of n(6)-methyladenosine modification residues (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488182/
https://www.ncbi.nlm.nih.gov/pubmed/31017262
http://dx.doi.org/10.3892/ijmm.2019.4169
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