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Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences

BACKGROUND: Follicular lymphoma (FL) is less prevalent in Asians, but detailed epidemiological analyses were not available. This study aimed to characterize the epidemiologic features of FL in Taiwan to explore the factors relevant to disease development and prognosis. METHODS: We obtained epidemiol...

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Autores principales: Wu, Shang‐Ju, Chen, Yi‐Chu, Lo, Wei‐Cheng, Chiang, Chun‐Ju, Lin, Chien‐Ting, Chuang, Shih‐Sung, Lai, Mei‐Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488204/
https://www.ncbi.nlm.nih.gov/pubmed/30791222
http://dx.doi.org/10.1002/cam4.2028
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author Wu, Shang‐Ju
Chen, Yi‐Chu
Lo, Wei‐Cheng
Chiang, Chun‐Ju
Lin, Chien‐Ting
Chuang, Shih‐Sung
Lai, Mei‐Shu
author_facet Wu, Shang‐Ju
Chen, Yi‐Chu
Lo, Wei‐Cheng
Chiang, Chun‐Ju
Lin, Chien‐Ting
Chuang, Shih‐Sung
Lai, Mei‐Shu
author_sort Wu, Shang‐Ju
collection PubMed
description BACKGROUND: Follicular lymphoma (FL) is less prevalent in Asians, but detailed epidemiological analyses were not available. This study aimed to characterize the epidemiologic features of FL in Taiwan to explore the factors relevant to disease development and prognosis. METHODS: We obtained epidemiological data for Taiwanese citizens during 1990‐2012 from Taiwan's National Cancer Registry Database, and the corresponding data for US Caucasians from the Surveillance, Epidemiology, and End Results Program. Changes in incidence rates were evaluated with age‐period‐cohort (APC) analyses. Patient outcomes were compared with 5‐year relative survival rates (RS) estimates. RESULTS: Incidence rates of FL in Taiwan increased continuously during the study period (0.34 to 0.91 per 100 000 person‐year from 1993‐1997 to 2008‐2012 in men, and from 0.29 [1993‐1997] to 0.81 [2008‐2012] in women), while rates in the US remained stable in both sexes, ranging between 3.73 and 3.96 in men and between 3.24 and 3.55 in women. Estimates of average annual percentage changes in incidence were significantly positive in Taiwan, but not in US Caucasians. Notably, the APC analysis identified a strong birth‐cohort effect in Taiwan, corresponding to environmental alterations present during the study period. The estimated 5‐year RS rates in both populations showed steady improvement, but the RS in Taiwanese patients was consistently 10% lower than in US Caucasians. CONCLUSION: A distinct increasing trend of incidence with a strong birth‐cohort effect was identified in Taiwan, providing evidence of the association between environmental factors and disease development.
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spelling pubmed-64882042019-05-23 Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences Wu, Shang‐Ju Chen, Yi‐Chu Lo, Wei‐Cheng Chiang, Chun‐Ju Lin, Chien‐Ting Chuang, Shih‐Sung Lai, Mei‐Shu Cancer Med Cancer Prevention BACKGROUND: Follicular lymphoma (FL) is less prevalent in Asians, but detailed epidemiological analyses were not available. This study aimed to characterize the epidemiologic features of FL in Taiwan to explore the factors relevant to disease development and prognosis. METHODS: We obtained epidemiological data for Taiwanese citizens during 1990‐2012 from Taiwan's National Cancer Registry Database, and the corresponding data for US Caucasians from the Surveillance, Epidemiology, and End Results Program. Changes in incidence rates were evaluated with age‐period‐cohort (APC) analyses. Patient outcomes were compared with 5‐year relative survival rates (RS) estimates. RESULTS: Incidence rates of FL in Taiwan increased continuously during the study period (0.34 to 0.91 per 100 000 person‐year from 1993‐1997 to 2008‐2012 in men, and from 0.29 [1993‐1997] to 0.81 [2008‐2012] in women), while rates in the US remained stable in both sexes, ranging between 3.73 and 3.96 in men and between 3.24 and 3.55 in women. Estimates of average annual percentage changes in incidence were significantly positive in Taiwan, but not in US Caucasians. Notably, the APC analysis identified a strong birth‐cohort effect in Taiwan, corresponding to environmental alterations present during the study period. The estimated 5‐year RS rates in both populations showed steady improvement, but the RS in Taiwanese patients was consistently 10% lower than in US Caucasians. CONCLUSION: A distinct increasing trend of incidence with a strong birth‐cohort effect was identified in Taiwan, providing evidence of the association between environmental factors and disease development. John Wiley and Sons Inc. 2019-02-21 /pmc/articles/PMC6488204/ /pubmed/30791222 http://dx.doi.org/10.1002/cam4.2028 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Wu, Shang‐Ju
Chen, Yi‐Chu
Lo, Wei‐Cheng
Chiang, Chun‐Ju
Lin, Chien‐Ting
Chuang, Shih‐Sung
Lai, Mei‐Shu
Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences
title Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences
title_full Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences
title_fullStr Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences
title_full_unstemmed Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences
title_short Distinctive incidence patterns of follicular lymphoma in Taiwan: Implications of ethnic differences
title_sort distinctive incidence patterns of follicular lymphoma in taiwan: implications of ethnic differences
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488204/
https://www.ncbi.nlm.nih.gov/pubmed/30791222
http://dx.doi.org/10.1002/cam4.2028
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