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Human cancer, the naked mole rat and faunal turnovers
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488205/ https://www.ncbi.nlm.nih.gov/pubmed/30790458 http://dx.doi.org/10.1002/cam4.2011 |
| Sumario: | We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer‐resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30‐50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment. |
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