Human cancer, the naked mole rat and faunal turnovers

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer...

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Detalles Bibliográficos
Autores principales: Bredberg, Anders, Schmitz, Birger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488205/
https://www.ncbi.nlm.nih.gov/pubmed/30790458
http://dx.doi.org/10.1002/cam4.2011
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author Bredberg, Anders
Schmitz, Birger
author_facet Bredberg, Anders
Schmitz, Birger
author_sort Bredberg, Anders
collection PubMed
description We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer‐resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30‐50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment.
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spelling pubmed-64882052019-05-23 Human cancer, the naked mole rat and faunal turnovers Bredberg, Anders Schmitz, Birger Cancer Med Cancer Biology We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer‐resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30‐50 million years ago. Research focusing on DNA stability mechanisms in ‘living fossil’ animals may help us find tools for cancer prevention and treatment. John Wiley and Sons Inc. 2019-02-21 /pmc/articles/PMC6488205/ /pubmed/30790458 http://dx.doi.org/10.1002/cam4.2011 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Bredberg, Anders
Schmitz, Birger
Human cancer, the naked mole rat and faunal turnovers
title Human cancer, the naked mole rat and faunal turnovers
title_full Human cancer, the naked mole rat and faunal turnovers
title_fullStr Human cancer, the naked mole rat and faunal turnovers
title_full_unstemmed Human cancer, the naked mole rat and faunal turnovers
title_short Human cancer, the naked mole rat and faunal turnovers
title_sort human cancer, the naked mole rat and faunal turnovers
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488205/
https://www.ncbi.nlm.nih.gov/pubmed/30790458
http://dx.doi.org/10.1002/cam4.2011
work_keys_str_mv AT bredberganders humancancerthenakedmoleratandfaunalturnovers
AT schmitzbirger humancancerthenakedmoleratandfaunalturnovers

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