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Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques
INTRODUCTION: In Congo, data on diabetic ketoacidosis (DKA) in children are old and rare. This study aims to describe the sociodemographic features of DKA and to identify risk factors for mortality. PATIENTS AND METHODS: We conducted an analytical study on DKA in childred at the University Hospital...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488241/ https://www.ncbi.nlm.nih.gov/pubmed/31086620 http://dx.doi.org/10.11604/pamj.2018.31.167.14415 |
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author | Oko, Aymar Pierre Gildas Ali, Fayçal Khalil Zaharo Mandilou, Steve Vassili Missambou Kambourou, Judicaël Letitia, Lombet Poathy, Jesse Pierre Yolaine Engoba, Moyen Ndjobo, Mamadou Ildevert Cyriaque Monabeka, Henri Germain Moyen, Georges Marius |
author_facet | Oko, Aymar Pierre Gildas Ali, Fayçal Khalil Zaharo Mandilou, Steve Vassili Missambou Kambourou, Judicaël Letitia, Lombet Poathy, Jesse Pierre Yolaine Engoba, Moyen Ndjobo, Mamadou Ildevert Cyriaque Monabeka, Henri Germain Moyen, Georges Marius |
author_sort | Oko, Aymar Pierre Gildas |
collection | PubMed |
description | INTRODUCTION: In Congo, data on diabetic ketoacidosis (DKA) in children are old and rare. This study aims to describe the sociodemographic features of DKA and to identify risk factors for mortality. PATIENTS AND METHODS: We conducted an analytical study on DKA in childred at the University Hospital in Brazzaville over the period from January 2013 to June 2016. We examined the socio-demographic, clinical, paraclinical and evolutionary variables. Chi-Square Test, Fisher’s exact test and odds ratio were used in the univariate analysis process and logistic regression model in the multivariate analysis. RESULTS: Out of 172 children hospitalized with diabetes 55 (31%) were hospitalized with ketoacidosis. They were girls (33; 60%) with an average age of 11.1± 4.9 years (ranging from 1 months to 17 years), 61.8% of parents came from low socioeconomic status. Ketoacidosis was the revealing symptom in 67.2 % of cases. The diagnosis made before hospitalization was wrong (50%). The triggering factor was often an infection (52.7%). Mortality rate was 12.7%. The risk factors for mortality in the univariate analysis were: age < 5 years (p=0,000006), average consultation time higher than 7 days (p= 0.001), severe dehydration (p = 0.0006), hemodynamic disorders (p= 0.0006), severe undernutrition (p= 0.02), Glasgow Coma Scale < 9 (p= 0.007) and diarrhea (p= 0.001). CONCLUSION: The importance and the seriousness of ketoacidosis impose preventive measures based on awareness, information and education campaigns as well as on the management of risk factors for mortality. |
format | Online Article Text |
id | pubmed-6488241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-64882412019-05-13 Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques Oko, Aymar Pierre Gildas Ali, Fayçal Khalil Zaharo Mandilou, Steve Vassili Missambou Kambourou, Judicaël Letitia, Lombet Poathy, Jesse Pierre Yolaine Engoba, Moyen Ndjobo, Mamadou Ildevert Cyriaque Monabeka, Henri Germain Moyen, Georges Marius Pan Afr Med J Research INTRODUCTION: In Congo, data on diabetic ketoacidosis (DKA) in children are old and rare. This study aims to describe the sociodemographic features of DKA and to identify risk factors for mortality. PATIENTS AND METHODS: We conducted an analytical study on DKA in childred at the University Hospital in Brazzaville over the period from January 2013 to June 2016. We examined the socio-demographic, clinical, paraclinical and evolutionary variables. Chi-Square Test, Fisher’s exact test and odds ratio were used in the univariate analysis process and logistic regression model in the multivariate analysis. RESULTS: Out of 172 children hospitalized with diabetes 55 (31%) were hospitalized with ketoacidosis. They were girls (33; 60%) with an average age of 11.1± 4.9 years (ranging from 1 months to 17 years), 61.8% of parents came from low socioeconomic status. Ketoacidosis was the revealing symptom in 67.2 % of cases. The diagnosis made before hospitalization was wrong (50%). The triggering factor was often an infection (52.7%). Mortality rate was 12.7%. The risk factors for mortality in the univariate analysis were: age < 5 years (p=0,000006), average consultation time higher than 7 days (p= 0.001), severe dehydration (p = 0.0006), hemodynamic disorders (p= 0.0006), severe undernutrition (p= 0.02), Glasgow Coma Scale < 9 (p= 0.007) and diarrhea (p= 0.001). CONCLUSION: The importance and the seriousness of ketoacidosis impose preventive measures based on awareness, information and education campaigns as well as on the management of risk factors for mortality. The African Field Epidemiology Network 2018-11-09 /pmc/articles/PMC6488241/ /pubmed/31086620 http://dx.doi.org/10.11604/pamj.2018.31.167.14415 Text en © Aymar Pierre Gildas Oko et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Oko, Aymar Pierre Gildas Ali, Fayçal Khalil Zaharo Mandilou, Steve Vassili Missambou Kambourou, Judicaël Letitia, Lombet Poathy, Jesse Pierre Yolaine Engoba, Moyen Ndjobo, Mamadou Ildevert Cyriaque Monabeka, Henri Germain Moyen, Georges Marius Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
title | Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
title_full | Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
title_fullStr | Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
title_full_unstemmed | Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
title_short | Acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
title_sort | acidocétose diabétique chez l’enfant: aspects épidémiologiques et pronostiques |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488241/ https://www.ncbi.nlm.nih.gov/pubmed/31086620 http://dx.doi.org/10.11604/pamj.2018.31.167.14415 |
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