Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

The immune system distinguishes between self and foreign antigens. The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the different ligand binding half-lives to the T cell receptor (TCR). It is challenging to test KPR as the available experimental sy...

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Detalles Bibliográficos
Autores principales: Yousefi, O Sascha, Günther, Matthias, Hörner, Maximilian, Chalupsky, Julia, Wess, Maximilian, Brandl, Simon M, Smith, Robert W, Fleck, Christian, Kunkel, Tim, Zurbriggen, Matias D, Höfer, Thomas, Weber, Wilfried, Schamel, Wolfgang WA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488296/
https://www.ncbi.nlm.nih.gov/pubmed/30947807
http://dx.doi.org/10.7554/eLife.42475

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