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Anterior insular cortex plays a critical role in interoceptive attention

Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attentio...

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Autores principales: Wang, Xingchao, Wu, Qiong, Egan, Laura, Gu, Xiaosi, Liu, Pinan, Gu, Hong, Yang, Yihong, Luo, Jing, Wu, Yanhong, Gao, Zhixian, Fan, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488299/
https://www.ncbi.nlm.nih.gov/pubmed/30985277
http://dx.doi.org/10.7554/eLife.42265
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author Wang, Xingchao
Wu, Qiong
Egan, Laura
Gu, Xiaosi
Liu, Pinan
Gu, Hong
Yang, Yihong
Luo, Jing
Wu, Yanhong
Gao, Zhixian
Fan, Jin
author_facet Wang, Xingchao
Wu, Qiong
Egan, Laura
Gu, Xiaosi
Liu, Pinan
Gu, Hong
Yang, Yihong
Luo, Jing
Wu, Yanhong
Gao, Zhixian
Fan, Jin
author_sort Wang, Xingchao
collection PubMed
description Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions. Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity. These results provide compelling evidence that the AIC plays a critical role in interoceptive attention.
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spelling pubmed-64882992019-05-01 Anterior insular cortex plays a critical role in interoceptive attention Wang, Xingchao Wu, Qiong Egan, Laura Gu, Xiaosi Liu, Pinan Gu, Hong Yang, Yihong Luo, Jing Wu, Yanhong Gao, Zhixian Fan, Jin eLife Neuroscience Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions. Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity. These results provide compelling evidence that the AIC plays a critical role in interoceptive attention. eLife Sciences Publications, Ltd 2019-04-15 /pmc/articles/PMC6488299/ /pubmed/30985277 http://dx.doi.org/10.7554/eLife.42265 Text en http://creativecommons.org/publicdomain/zero/1.0/ http://creativecommons.org/publicdomain/zero/1.0/This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) .
spellingShingle Neuroscience
Wang, Xingchao
Wu, Qiong
Egan, Laura
Gu, Xiaosi
Liu, Pinan
Gu, Hong
Yang, Yihong
Luo, Jing
Wu, Yanhong
Gao, Zhixian
Fan, Jin
Anterior insular cortex plays a critical role in interoceptive attention
title Anterior insular cortex plays a critical role in interoceptive attention
title_full Anterior insular cortex plays a critical role in interoceptive attention
title_fullStr Anterior insular cortex plays a critical role in interoceptive attention
title_full_unstemmed Anterior insular cortex plays a critical role in interoceptive attention
title_short Anterior insular cortex plays a critical role in interoceptive attention
title_sort anterior insular cortex plays a critical role in interoceptive attention
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488299/
https://www.ncbi.nlm.nih.gov/pubmed/30985277
http://dx.doi.org/10.7554/eLife.42265
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