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Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review
By contrast to clinical trials exploring osteoporosis, clinical trials specifically designed for the osteopenic population are limited. Thus, less clinical data are available regarding treatment benefits and cost-effectiveness of treating a patient population with a bone mass density in the osteopen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488345/ https://www.ncbi.nlm.nih.gov/pubmed/31058029 http://dx.doi.org/10.7759/cureus.4146 |
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author | Iqbal, Shumaila M Qamar, Iqra Zhi, Cassandra Nida, Anum Aslam, Hafiz M |
author_facet | Iqbal, Shumaila M Qamar, Iqra Zhi, Cassandra Nida, Anum Aslam, Hafiz M |
author_sort | Iqbal, Shumaila M |
collection | PubMed |
description | By contrast to clinical trials exploring osteoporosis, clinical trials specifically designed for the osteopenic population are limited. Thus, less clinical data are available regarding treatment benefits and cost-effectiveness of treating a patient population with a bone mass density in the osteopenic range (T-score between -1 and -2.5). In this article, we aimed to highlight this high-risk population with a low bone mass density (BMD) susceptible to high fracture risk by reviewing different national and international guidelines for treating osteopenia. The cost-effectiveness of the therapy for the above-mentioned patient population is also discussed. By reviewing different clinical trials, we have specifically highlighted the role of bisphosphonate therapy for fracture risk reduction and increment in bone mineral density (BMD) in patients with osteopenia. |
format | Online Article Text |
id | pubmed-6488345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-64883452019-05-05 Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review Iqbal, Shumaila M Qamar, Iqra Zhi, Cassandra Nida, Anum Aslam, Hafiz M Cureus Endocrinology/Diabetes/Metabolism By contrast to clinical trials exploring osteoporosis, clinical trials specifically designed for the osteopenic population are limited. Thus, less clinical data are available regarding treatment benefits and cost-effectiveness of treating a patient population with a bone mass density in the osteopenic range (T-score between -1 and -2.5). In this article, we aimed to highlight this high-risk population with a low bone mass density (BMD) susceptible to high fracture risk by reviewing different national and international guidelines for treating osteopenia. The cost-effectiveness of the therapy for the above-mentioned patient population is also discussed. By reviewing different clinical trials, we have specifically highlighted the role of bisphosphonate therapy for fracture risk reduction and increment in bone mineral density (BMD) in patients with osteopenia. Cureus 2019-02-27 /pmc/articles/PMC6488345/ /pubmed/31058029 http://dx.doi.org/10.7759/cureus.4146 Text en Copyright © 2019, Iqbal et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Iqbal, Shumaila M Qamar, Iqra Zhi, Cassandra Nida, Anum Aslam, Hafiz M Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review |
title | Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review |
title_full | Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review |
title_fullStr | Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review |
title_full_unstemmed | Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review |
title_short | Role of Bisphosphonate Therapy in Patients with Osteopenia: A Systemic Review |
title_sort | role of bisphosphonate therapy in patients with osteopenia: a systemic review |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488345/ https://www.ncbi.nlm.nih.gov/pubmed/31058029 http://dx.doi.org/10.7759/cureus.4146 |
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