Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer

Therapeutic targeting of phosphatidyl-inositol 3-kinase (PI3K) is considered as a possible strategy in several types of cancer, including gastrointestinal ones. In vitro and in vivo studies indicated the significance of proapoptotic and antiproliferative inhibition of PI3K. Although there are many p...

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Detalles Bibliográficos
Autores principales: Hashemzadeh, Kamelia, Jokar, Mohammad Hassan, Sedighi, Sima, Moradzadeh, Maliheh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488499/
https://www.ncbi.nlm.nih.gov/pubmed/31049177
http://dx.doi.org/10.15171/mejdd.2018.122
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author Hashemzadeh, Kamelia
Jokar, Mohammad Hassan
Sedighi, Sima
Moradzadeh, Maliheh
author_facet Hashemzadeh, Kamelia
Jokar, Mohammad Hassan
Sedighi, Sima
Moradzadeh, Maliheh
author_sort Hashemzadeh, Kamelia
collection PubMed
description Therapeutic targeting of phosphatidyl-inositol 3-kinase (PI3K) is considered as a possible strategy in several types of cancer, including gastrointestinal ones. In vitro and in vivo studies indicated the significance of proapoptotic and antiproliferative inhibition of PI3K. Although there are many phase 1 and 2 clinical trials on PI3K inhibitors in patients with gastrointestinal cancer, the molecular mechanism of PI3K targeting PI3K/ mTOR pathway is not clear. Panclass I, isoformselective, and dual PI3K/mTOR inhibitors are under investigation. This review aimed to indicate PI3K-dependent targeting mechanisms in gastrointestinal cancer and the evaluation of related clinical data.
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spelling pubmed-64884992019-05-02 Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer Hashemzadeh, Kamelia Jokar, Mohammad Hassan Sedighi, Sima Moradzadeh, Maliheh Middle East J Dig Dis Review Article Therapeutic targeting of phosphatidyl-inositol 3-kinase (PI3K) is considered as a possible strategy in several types of cancer, including gastrointestinal ones. In vitro and in vivo studies indicated the significance of proapoptotic and antiproliferative inhibition of PI3K. Although there are many phase 1 and 2 clinical trials on PI3K inhibitors in patients with gastrointestinal cancer, the molecular mechanism of PI3K targeting PI3K/ mTOR pathway is not clear. Panclass I, isoformselective, and dual PI3K/mTOR inhibitors are under investigation. This review aimed to indicate PI3K-dependent targeting mechanisms in gastrointestinal cancer and the evaluation of related clinical data. Iranian Association of Gastroerterology and Hepatology 2019-01 2018-11-21 /pmc/articles/PMC6488499/ /pubmed/31049177 http://dx.doi.org/10.15171/mejdd.2018.122 Text en © 2019 The Author(s) This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Review Article
Hashemzadeh, Kamelia
Jokar, Mohammad Hassan
Sedighi, Sima
Moradzadeh, Maliheh
Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer
title Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer
title_full Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer
title_fullStr Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer
title_full_unstemmed Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer
title_short Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer
title_sort therapeutic potency of pi3k pharmacological inhibitors of gastrointestinal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488499/
https://www.ncbi.nlm.nih.gov/pubmed/31049177
http://dx.doi.org/10.15171/mejdd.2018.122
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AT sedighisima therapeuticpotencyofpi3kpharmacologicalinhibitorsofgastrointestinalcancer
AT moradzadehmaliheh therapeuticpotencyofpi3kpharmacologicalinhibitorsofgastrointestinalcancer

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