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A rare case of near-haploid acute lymphoblastic leukemia
Near-haploid acute lymphoblastic leukemia is seen in <1% of cases and carries an unfavorable prognosis. We report a case in an 18-year old male. He presented with two abnormal clones, one with 27–28 and one with 54–56 chromosomes. Near-haploidy (27–28) carries a poor prognosis and hyperdiploidy (...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488524/ https://www.ncbi.nlm.nih.gov/pubmed/31061791 http://dx.doi.org/10.1016/j.lrr.2019.04.006 |
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author | Gonzalez-Marques, William Zaslav, Ann-Leslie Balakrishnan, Dhana Hogan, Laura Ma, Yupo Tully, Daniel Fernicola, Paula Ponce, Roxana Lee, Htien Mercado, Theresa Ahmed, Tahmeena |
author_facet | Gonzalez-Marques, William Zaslav, Ann-Leslie Balakrishnan, Dhana Hogan, Laura Ma, Yupo Tully, Daniel Fernicola, Paula Ponce, Roxana Lee, Htien Mercado, Theresa Ahmed, Tahmeena |
author_sort | Gonzalez-Marques, William |
collection | PubMed |
description | Near-haploid acute lymphoblastic leukemia is seen in <1% of cases and carries an unfavorable prognosis. We report a case in an 18-year old male. He presented with two abnormal clones, one with 27–28 and one with 54–56 chromosomes. Near-haploidy (27–28) carries a poor prognosis and hyperdiploidy (>50) has a good prognosis. The correct diagnosis was critical for this patient's prognosis and treatment. The patient achieved remission after a bone marrow transplant from a 10/10 HLA matched sibling donor. He relapsed six months later and expired seven months later. This case illustrates the need for careful standard and molecular cytogenetic analysis for accurate diagnosis and treatment for this rare type of ALL. |
format | Online Article Text |
id | pubmed-6488524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-64885242019-05-06 A rare case of near-haploid acute lymphoblastic leukemia Gonzalez-Marques, William Zaslav, Ann-Leslie Balakrishnan, Dhana Hogan, Laura Ma, Yupo Tully, Daniel Fernicola, Paula Ponce, Roxana Lee, Htien Mercado, Theresa Ahmed, Tahmeena Leuk Res Rep Article Near-haploid acute lymphoblastic leukemia is seen in <1% of cases and carries an unfavorable prognosis. We report a case in an 18-year old male. He presented with two abnormal clones, one with 27–28 and one with 54–56 chromosomes. Near-haploidy (27–28) carries a poor prognosis and hyperdiploidy (>50) has a good prognosis. The correct diagnosis was critical for this patient's prognosis and treatment. The patient achieved remission after a bone marrow transplant from a 10/10 HLA matched sibling donor. He relapsed six months later and expired seven months later. This case illustrates the need for careful standard and molecular cytogenetic analysis for accurate diagnosis and treatment for this rare type of ALL. Elsevier 2019-04-22 /pmc/articles/PMC6488524/ /pubmed/31061791 http://dx.doi.org/10.1016/j.lrr.2019.04.006 Text en Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Gonzalez-Marques, William Zaslav, Ann-Leslie Balakrishnan, Dhana Hogan, Laura Ma, Yupo Tully, Daniel Fernicola, Paula Ponce, Roxana Lee, Htien Mercado, Theresa Ahmed, Tahmeena A rare case of near-haploid acute lymphoblastic leukemia |
title | A rare case of near-haploid acute lymphoblastic leukemia |
title_full | A rare case of near-haploid acute lymphoblastic leukemia |
title_fullStr | A rare case of near-haploid acute lymphoblastic leukemia |
title_full_unstemmed | A rare case of near-haploid acute lymphoblastic leukemia |
title_short | A rare case of near-haploid acute lymphoblastic leukemia |
title_sort | rare case of near-haploid acute lymphoblastic leukemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488524/ https://www.ncbi.nlm.nih.gov/pubmed/31061791 http://dx.doi.org/10.1016/j.lrr.2019.04.006 |
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