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Intestinal-type adenocarcinoma of the vulva: A case study

Approximately 5% of all gynecologic cancers are of the vulva, of which 90% are squamous cell in origin. Adenocarcinomas of the vulva are extremely infrequent with most relating to epithelial glands in the vulvar region. A 53 year old African American female presented to the emergency department comp...

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Autores principales: Kaltenecker, Brian, Manos, Robert, McCall, Meagan, Sparzak, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488529/
https://www.ncbi.nlm.nih.gov/pubmed/31061870
http://dx.doi.org/10.1016/j.gore.2019.03.017
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author Kaltenecker, Brian
Manos, Robert
McCall, Meagan
Sparzak, Paul
author_facet Kaltenecker, Brian
Manos, Robert
McCall, Meagan
Sparzak, Paul
author_sort Kaltenecker, Brian
collection PubMed
description Approximately 5% of all gynecologic cancers are of the vulva, of which 90% are squamous cell in origin. Adenocarcinomas of the vulva are extremely infrequent with most relating to epithelial glands in the vulvar region. A 53 year old African American female presented to the emergency department complaining of a lesion on her left labia that had been present for the past 6 months. In the operating room, multiple biopsies were taken of the left labial lesion as well as the right, and sufficient tissue was sent to pathology for analysis. The pathology report demonstrated adenocarcinoma of the vulva with intestinal type features, CD20+, CK7-, mCEA+, vimentin -, p53+. These findings were consistent with a colorectal primary; however, no colorectal primary was discovered. The intestinal type of primary adenocarcinoma of the vulva is a rare variant, and only a few cases have been reported to date. It histologically resembles mucinous colonic carcinomas, but immunohistochemical workups with various tumor markers are needed before confirmation.
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spelling pubmed-64885292019-05-06 Intestinal-type adenocarcinoma of the vulva: A case study Kaltenecker, Brian Manos, Robert McCall, Meagan Sparzak, Paul Gynecol Oncol Rep Case Report Approximately 5% of all gynecologic cancers are of the vulva, of which 90% are squamous cell in origin. Adenocarcinomas of the vulva are extremely infrequent with most relating to epithelial glands in the vulvar region. A 53 year old African American female presented to the emergency department complaining of a lesion on her left labia that had been present for the past 6 months. In the operating room, multiple biopsies were taken of the left labial lesion as well as the right, and sufficient tissue was sent to pathology for analysis. The pathology report demonstrated adenocarcinoma of the vulva with intestinal type features, CD20+, CK7-, mCEA+, vimentin -, p53+. These findings were consistent with a colorectal primary; however, no colorectal primary was discovered. The intestinal type of primary adenocarcinoma of the vulva is a rare variant, and only a few cases have been reported to date. It histologically resembles mucinous colonic carcinomas, but immunohistochemical workups with various tumor markers are needed before confirmation. Elsevier 2019-03-29 /pmc/articles/PMC6488529/ /pubmed/31061870 http://dx.doi.org/10.1016/j.gore.2019.03.017 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kaltenecker, Brian
Manos, Robert
McCall, Meagan
Sparzak, Paul
Intestinal-type adenocarcinoma of the vulva: A case study
title Intestinal-type adenocarcinoma of the vulva: A case study
title_full Intestinal-type adenocarcinoma of the vulva: A case study
title_fullStr Intestinal-type adenocarcinoma of the vulva: A case study
title_full_unstemmed Intestinal-type adenocarcinoma of the vulva: A case study
title_short Intestinal-type adenocarcinoma of the vulva: A case study
title_sort intestinal-type adenocarcinoma of the vulva: a case study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488529/
https://www.ncbi.nlm.nih.gov/pubmed/31061870
http://dx.doi.org/10.1016/j.gore.2019.03.017
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