Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography

Positron emission tomography (PET) imaging with radiolabeled drugs holds great promise to assess the influence of membrane transporters on hepatobiliary clearance of drugs. To exploit the full potential of PET, quantitative pharmacokinetic models are required. In this study, we evaluated the suitabi...

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Detalles Bibliográficos
Autores principales: Hernández Lozano, Irene, Karch, Rudolf, Bauer, Martin, Blaickner, Matthias, Matsuda, Akihiro, Wulkersdorfer, Beatrix, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488550/
https://www.ncbi.nlm.nih.gov/pubmed/31037511
http://dx.doi.org/10.1208/s12248-019-0323-0

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