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PulmoBind Imaging Measures Reduction of Vascular Adrenomedullin Receptor Activity with Lack of effect of Sildenafil in Pulmonary Hypertension

Endothelial dysfunction is a core pathophysiologic process in pulmonary arterial hypertension (PAH). We developed PulmoBind (PB), a novel imaging biomarker of the pulmonary vascular endothelium. (99m)Technetium ((99m)Tc)-labelled PB binds to adrenomedullin receptors (AM(1)) densely expressed in the...

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Detalles Bibliográficos
Autores principales:	Merabet, Nassiba, Nsaibia, Mohamed Jalloul, Nguyen, Quang Trinh, Shi, Yan Fen, Letourneau, Myriam, Fournier, Alain, Tardif, Jean-Claude, Harel, François, Dupuis, Jocelyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488585/ https://www.ncbi.nlm.nih.gov/pubmed/31036871 http://dx.doi.org/10.1038/s41598-019-43225-3

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