Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells

We present evidence for the decomposition and oxidation of amino acids in aqueous solution following irradiation with a nonequilibrium plasma jet. Of 15 amino acids tested in cell culture medium, plasma irradiation induced a marked chemical change in methionine and tryptophan due to the effective pr...

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Autores principales: Uchida, Giichiro, Mino, Yusuke, Suzuki, Tensho, Ikeda, Jun-ichiro, Suzuki, Takashi, Takenaka, Kosuke, Setsuhara, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488654/
https://www.ncbi.nlm.nih.gov/pubmed/31036847
http://dx.doi.org/10.1038/s41598-019-42959-4
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author Uchida, Giichiro
Mino, Yusuke
Suzuki, Tensho
Ikeda, Jun-ichiro
Suzuki, Takashi
Takenaka, Kosuke
Setsuhara, Yuichi
author_facet Uchida, Giichiro
Mino, Yusuke
Suzuki, Tensho
Ikeda, Jun-ichiro
Suzuki, Takashi
Takenaka, Kosuke
Setsuhara, Yuichi
author_sort Uchida, Giichiro
collection PubMed
description We present evidence for the decomposition and oxidation of amino acids in aqueous solution following irradiation with a nonequilibrium plasma jet. Of 15 amino acids tested in cell culture medium, plasma irradiation induced a marked chemical change in methionine and tryptophan due to the effective production of reactive oxygen species by plasma-water interaction. We also report that plasma-treated methionine and tryptophan aqueous solutions can kill cancer cells, greatly decreasing the viability of human endometrial carcinoma (HEC-1) cancer cells due to the presence of decomposition or oxidation products generated from the amino acid. Plasma-treated methionine and tryptophan aqueous solutions also induced an anti-cancer effect on cancer-initiating cells.
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spelling pubmed-64886542019-05-16 Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells Uchida, Giichiro Mino, Yusuke Suzuki, Tensho Ikeda, Jun-ichiro Suzuki, Takashi Takenaka, Kosuke Setsuhara, Yuichi Sci Rep Article We present evidence for the decomposition and oxidation of amino acids in aqueous solution following irradiation with a nonequilibrium plasma jet. Of 15 amino acids tested in cell culture medium, plasma irradiation induced a marked chemical change in methionine and tryptophan due to the effective production of reactive oxygen species by plasma-water interaction. We also report that plasma-treated methionine and tryptophan aqueous solutions can kill cancer cells, greatly decreasing the viability of human endometrial carcinoma (HEC-1) cancer cells due to the presence of decomposition or oxidation products generated from the amino acid. Plasma-treated methionine and tryptophan aqueous solutions also induced an anti-cancer effect on cancer-initiating cells. Nature Publishing Group UK 2019-04-29 /pmc/articles/PMC6488654/ /pubmed/31036847 http://dx.doi.org/10.1038/s41598-019-42959-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Uchida, Giichiro
Mino, Yusuke
Suzuki, Tensho
Ikeda, Jun-ichiro
Suzuki, Takashi
Takenaka, Kosuke
Setsuhara, Yuichi
Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
title Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
title_full Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
title_fullStr Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
title_full_unstemmed Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
title_short Decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
title_sort decomposition and oxidation of methionine and tryptophan following irradiation with a nonequilibrium plasma jet and applications for killing cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488654/
https://www.ncbi.nlm.nih.gov/pubmed/31036847
http://dx.doi.org/10.1038/s41598-019-42959-4
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