FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation and, if defective, is associated with autoimmune disease, yet its impact on specific B...

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Detalles Bibliográficos
Autores principales: Espéli, Marion, Bashford-Rogers, Rachael, Sowerby, John M., Alouche, Nagham, Wong, Limy, Denton, Alice E., Linterman, Michelle A., Smith, Kenneth G. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488660/
https://www.ncbi.nlm.nih.gov/pubmed/31036800
http://dx.doi.org/10.1038/s41467-019-09434-0

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