Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-lik...

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Autores principales: Ramdhan, N.D., Blom, J., Sutcliffe, I.C., Pereira-Ribeiro, P.M.A., Santos, C.S., Mattos-Guaraldi, A.L., Burkovski, A., Sangal, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488682/
https://www.ncbi.nlm.nih.gov/pubmed/31061711
http://dx.doi.org/10.1016/j.nmni.2019.100544
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author Ramdhan, N.D.
Blom, J.
Sutcliffe, I.C.
Pereira-Ribeiro, P.M.A.
Santos, C.S.
Mattos-Guaraldi, A.L.
Burkovski, A.
Sangal, V.
author_facet Ramdhan, N.D.
Blom, J.
Sutcliffe, I.C.
Pereira-Ribeiro, P.M.A.
Santos, C.S.
Mattos-Guaraldi, A.L.
Burkovski, A.
Sangal, V.
author_sort Ramdhan, N.D.
collection PubMed
description The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
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spelling pubmed-64886822019-05-06 Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient Ramdhan, N.D. Blom, J. Sutcliffe, I.C. Pereira-Ribeiro, P.M.A. Santos, C.S. Mattos-Guaraldi, A.L. Burkovski, A. Sangal, V. New Microbes New Infect Original Article The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics. Elsevier 2019-04-09 /pmc/articles/PMC6488682/ /pubmed/31061711 http://dx.doi.org/10.1016/j.nmni.2019.100544 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Ramdhan, N.D.
Blom, J.
Sutcliffe, I.C.
Pereira-Ribeiro, P.M.A.
Santos, C.S.
Mattos-Guaraldi, A.L.
Burkovski, A.
Sangal, V.
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
title Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
title_full Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
title_fullStr Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
title_full_unstemmed Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
title_short Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
title_sort genomic analysis of a novel nontoxigenic corynebacterium diphtheriae strain isolated from a cancer patient
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488682/
https://www.ncbi.nlm.nih.gov/pubmed/31061711
http://dx.doi.org/10.1016/j.nmni.2019.100544
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