Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Tetsuya, Shishido, Tetsuro, Kinoshita, Daisuke, Watanabe, Ken, Toshima, Taku, Sugai, Takayuki, Narumi, Taro, Otaki, Yoichiro, Tamura, Harutoshi, Nishiyama, Satoshi, Arimoto, Takanori, Takahashi, Hiroki, Miyamoto, Takuya, Watanabe, Tetsu, Woo, Chang-Hoon, Abe, Jun-ichi, Takeishi, Yasuchika, Kubota, Isao, Watanabe, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488753/
https://www.ncbi.nlm.nih.gov/pubmed/31061925
http://dx.doi.org/10.1016/j.jacbts.2018.11.011
Descripción
Sumario:High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac-specific HMGB1 overexpression transgenic mice after angiotensin II stimulation as compared with wild-type mice. In vitro, inhibition of HMGB1 increased phosphorylation of extracellular signal-related kinase 1/2 and nuclear factor kappa B, which was rescued by DDR inhibitor treatment. DDR inhibitor treatment provided a cardioprotective effect on angiotensin II–induced cardiac remodeling in mice.

Ejemplares similares